Abstract
Human activities every day have a lot of physical contact with the environment, this can cause various kinds of diseases. These diseases can come from various types of microorganisms such as bacteria, fungi and viruses. Examples of bacteria that can cause disease are Escherichia coli and Staphylococcus aureus. Escherichia coli and Staphylococcus aureus are Gram-positive and Gram-negative bacteria that most commonly cause diarrhoea. To avoid these bacteria, humans need to wash their hands using soap and clean running water. However, washing hands cannot be done every time and in every place. Therefore, there is an innovation of hand sanitizer without using running water, namely hand sanitizer. Hand sanitizer is a waterless hand sanitizer innovation that contains antiseptic substances. Hand sanitizer works as an antibacterial in inhibiting and even killing bacteria. Antiseptics are chemical compounds used to inhibit or kill microorganisms in living tissue. The purpose of using antiseptics is to inhibit or kill bacteria by inhibiting bacterial enzymes and reducing the permeability of bacterial cell membranes through bacterial precipitation, oxidation, and halogenation. Antiseptics usually contain alcohol, chlorhexidine, and anilides. Antiseptics that are widely used in the medical world are antiseptics with alcohol content based on the ability of alcohol to kill bacteria.
References
Andriyansyah, I., Setyawati, B., Yulvianti, M., Kertikasari, D., & Kustiningsih, I. (2022). Penyuluhan mengenai hand sanitizer sebagai bentuk pencegahan Covid-19 di Desa Angsana Kabupaten Serang. In Prosiding Seminar Nasional Pengabdian Masyarakat LPPM UMJ (Vol. 1, No. 1).
Aprilia, H., & Arumsari, A. (2015). Uji pembandingan efektivitas antiseptik strong acidic water terhadap antiseptik standar etanol 70%. Prosiding Farmasi, 217-222.
Cheung, H. Y., Wong, M. M. K., Cheung, S. H, Liang, L. Y. , Lam Y. W., dan Chiu, S. K. (2012). Differential actions of chlorhexidine on the cell wall of Bacillus subtilis and Escherichia coli. PLOS ONE. 7(5): e36659.
Deshpande, A., Fox, J., Wong, K. K., Cadnum, J. L., Sankar, T., Jencson, A., & Gordon, S. (2018). Comparative antimicrobial efficacy of two hand sanitizers in intensive care units common areas: A randomized, controlled trial. Infection control & hospital epidemiology, 39(3), 267-271.
Diana, C., Misnawi, Diyantika, D. (2017). Perubahan morfologi Staphylococcus aureus akibat paparan ekstrak etanol biji kakao (Theobroma cacao) secara In Vitro. Fakultas kedokteran. Universitas Jember. Jawa Timur.
Elizabeth, R., Apriliana, E., & Rukmono, P. (2013). Uji efektivitas pada antiseptik di unit perinatologi Rumah Sakit Umum Abdul Moeloek Bandar Lampung. Jurnal Majority, 2(5).
Emelda, E., Asriani Safitri, E., & Fatmawati, A. (2021). Inhibition Activity Of Ethanolic Extract Of Ulva lactuca Against Staphylococcus aureus. In Pharmaceutical Journal of Indonesia (Vol. 7, Issue 1, pp. 43–48). Brawijaya University. https://doi.org/10.21776/ub.pji.2021.007.01.7
Hapsari, M. E. (2015). Uji Aktivitas Antibakteri Ekstrak Herba Meniran (Phyllanthus niruri) Terhadap pertumbuhan Bakteri Bacillus cereus dan Escherichia coli. Universitas Sanata Dharma. Yogyakarta.
Ivanka, Mey, D., & Puspitasari, Irma M. (2022). Artikel review: Mekanisme kerja bahan penyusun utama antiseptik dan desinfektan dalam menurunkan risiko penularan covid-19 bagi tenaga kerja kesehatan di rumah sakit. Farmaka, 20(3), 63-74.
Kusuma, Y., Pinatih, K. J. P., dan Hendrayana, M. A. (2019). Efek sinergis kombinasi chlorhexidine dan alkohol terhadap daya hambat pertumbuhan Staphylococcus aureus. E-Jurnal Medika. 8(3).
Lim K.S., dan Kam P.C. (2008). Chlorhexidine--pharmacology and clinical applications. Anaesth Intensive Care. 36(4):502-12. doi: 10.1177/0310057X0803600404. PMID: 18714617.
Moeller, K. (2018). Breaking Proteins. ASU - Ask A Biologist. from https://askabiologist.asu.edu/activities/breaking-proteins
Negash, W., Dessalegn, M., Yitayew, B., Demsie, M., Wagnew, M., & Nyagero, J. (2016). Reproductive health service utilization and associated factors: the case of north Shewa zone youth, Amhara region, Ethiopia. The Pan African medical journal, 25(Suppl 2), 3.
Pratami, S., Pradika, Y. (2023). Identifikasi bakteri penyebab infeksi nosokomial (Pseudomonas aeruginosa) pada lantai Intensive Care Unit (ICU). Sekolah Tinggi Ilmu Kesehatan Kesetiakawanan Sosial Indonesia, Jakarta.
Poppolo Deus, F., & Ouanounou, A. (2022). Chlorhexidine in dentistry: pharmacology, uses, and adverse effects. International dental journal. 72(3):269–277.
Radji, M., Suryadi, H., & Ariyanti, D. (2007). Uji efektivitas antimikroba beberapa merek dagang pembersih tangan antiseptik. Majalah ilmu kefarmasian, 4(1), 1–6.
Rini, E. P. dan Nugraheni, E. R. (2018). Uji daya hambat berbagai merek hand sanitizer gel terhadap pertumbuhan bakteri Escherichia coli dan Staphylococcus aureus. Journal of Pharmaceutical Science and Clinical Research. 01: 18–26.
Thaddeus, N. I., Francis, E. C., Jane, O. O., Obumneme, A. C., and Okechukwu, E.C. (2018). Effects of some common additives on the antimicrobial activities of alcohol-based hand sanitizer. Asian Pacific Journal of Tropical Medicine, 11(3),222-226.
All articles submitted by the author and published in the Journal of Research in Pharmacy and Pharmaceutical Sciences, are fully copyrighted by the publication of JJournal of Research in Pharmacy and Pharmaceutical Sciences under the Creative Commons Attribution-NonCommercial 4.0 International License by technically filling out the copyright transfer agreement and sending it to the publisher
Note :
The author can include in separate contractual arrangements for the non-exclusive distribution of rich versions of journal publications (for example: posting them to an institutional repository or publishing them in a book), with the acknowledgment of their initial publication in this journal.
Authors are permitted and encouraged to post their work online (for example: in an institutional repository or on their website) before and during the submission process because it can lead to productive exchanges, as well as earlier and more powerful citations of published works. (See Open Access Effects).