Clinical Characteristics of Children with Refrative Amblyopia at Cipto Mangunkusumo National Referral Hospital

Authors

  • Dian Estu Yulia Fakultas Kedokteran, Universitas Indonesia, Jakarta, Indonesia
  • Julie Dewi Barliana Fakultas Kedokteran, Universitas Indonesia, Jakarta, Indonesia
  • Rita Sita Sitorus Departemen Ilmu Mata, Fakultas Kedokteran, Universitas Indonesia, Jakarta, Indonesia
  • Meuthia Rana Putri Fakultas Kedokteran, Universitas Indonesia, Jakarta, Indonesia
  • Diajeng Ayesha Soeharto Fakultas Kedokteran, Universitas Indonesia, Jakarta, Indonesia

DOI:

https://doi.org/10.33533/jpm.v18i1.7582

Keywords:

Amblyopia, Children, Refraction, Spectacles

Abstract

Amblyopia, commonly referred to as 'lazy eye’, manifests as a reduction in best corrected visual acuity (BCVA) in the absence of detectable ocular structural abnormalities. Refractive amblyopia specifically denotes a subtype of amblyopia arising from uncorrected refractive errors. A retrospective descriptive analysis was conducted on medical records of all pediatric patients with refractive amblyopia at the Department of Ophthalmology, Cipto Mangunkusumo Kirana National Referral Hospital, Jakarta, Indonesia in 2018 to 2022. A total of 391 eyes of 224 patients were included. Median age was 8 (5-18) years, with majority being older than 7 years of age (58.7%). Leading method of treatment was with spectacles alone (80.4%). Overall amblyopia improvement was mostly observed after six months of treatment. In conclusion, refractive amblyopia at our hospital was highly prevalent among children. Thus, early detection and treatment of refractive errors in children is essential to prevent refractive amblyopia.

References

Chen AM, Cotter SA. The Amblyopia Treatment Studies: Implications for Clinical Practice. Adv Ophthalmol Optom. 2016;1(1):287-305. DOI: https://doi.org/10.1016/j.yaoo.2016.03.007.

Joseph E, Ck M, Kumar R, et al. Prevalence of refractive errors among school-going children in a multistate study in India. Br J Ophthalmol. 2022. DOI: https://doi.org/10.1136/bjo-2022-322123

Hashemi H, Fotouhi A, Yekta A, et al. Global and regional estimates of prevalence of refractive errors: Systematic review and meta-analysis. J Curr Ophthalmol. 2018;30(1):3-22. DOI: https://doi.org/10.1016/j.joco.2017.08.009

Birch EE, Kelly KR. Amblyopia and the whole child. Prog Retin Eye Res. 2023;93:101168. DOI: https://doi.org/10.1016/j.preteyeres.2023.101168

Hashemi H, Nabovati P, Pakzad R, et al. Prevalence of amblyopia and its determinants in a rural population: a population-based cross-sectional study. Strabismus. 2021;29(1):10-8. DOI: https://doi.org/10.1080/09273972.2020.1871375

Hu B, Liu Z, Zhao J, et al. The Global Prevalence of Amblyopia in Children: A Systematic Review and Meta-Analysis. Front Pediatr. 2022;10:819998. DOI: https://doi.org/10.3389/fped.2022.819998

Anggraini N SL, Prihartono J, Suardana GG. Prevalensi Ambliopia dan Sebaran Faktor Ambliogenik Pada Murid Sekolah Dasar Negeri di Jakarta. Universitas Indonesia. 2006.

Magdalene D, Bhattacharjee H, Choudhury M, et al. Community outreach: An indicator for assessment of prevalence of amblyopia. Indian J Ophthalmol. 2018;66(7):940-4. DOI: https://doi.org/10.4103/ijo.IJO_1335_17

Handa S, Chia A. Amblyopia therapy in Asian children: factors affecting visual outcome and parents' perception of children's attitudes towards amblyopia treatment. Singapore Med J. 2019;60(6):291-7. DOI: https://doi.org/10.11622/smedj.2018151

Robert W. Hered AS, Braverman RS, Khan AO, Lee KA, Lueder GT, et al. Amblyopia. 2021-2022 Basic and Clinical Science Course, Section 6: Pediatric Ophthalmology and Strabismus. San Fransisco: American Academic of Ophthalmology; 2021.

Dirani M, Chan YH, Gazzard G, et al. Prevalence of refractive error in Singaporean Chinese children: the strabismus, amblyopia, and refractive error in young Singaporean Children (STARS) study. Invest Ophthalmol Vis Sci. 2010;51(3):1348-55. DOI: https://doi.org/10.1167/iovs.09-3587

Sharma IP, Lepcha NT, Lhamo T, et al. Visual impairment and refractive error in school children in Bhutan: The findings from the Bhutan School Sight Survey (BSSS 2019). PLoS One. 2020;15(9):e0239117. DOI: https://doi.org/10.1371/journal.pone.0239117

Rudnicka AR, Owen CG, Nightingale CM, Cook DG, Whincup PH. Ethnic differences in the prevalence of myopia and ocular biometry in 10- and 11-year-old children: the Child Heart and Health Study in England (CHASE). Invest Ophthalmol Vis Sci. 2010;51(12):6270-6. DOI: https://doi.org/10.1167/iovs.10-5528

Black AA, Wood JM, Hoang S, Thomas E, Webber AL. Impact of Amblyopia on Visual Attention and Visual Search in Children. Investigative Ophthalmology & Visual Science. 2021;62(4):15-. DOI: https://doi.org/10.1167/iovs.62.4.15

Hatt SR, Leske DA, Castañeda YS, et al. Understanding the Impact of Residual Amblyopia on Functional Vision and Eye-related Quality of Life Using the PedEyeQ. Am J Ophthalmol. 2020;218:173-81. DOI: https://doi.org/10.1016/j.ajo.2020.05.039

Mir Norouzi D, Dao L, Beauchamp C, et al. Assessing the contribution of eye movements to slow binocular reading in children with amblyopia. Journal of Vision. 2022;22(14):3106-. DOI: https://doi.org/10.1167/jov.22.14.3106

Faghihi M, Hashemi H, Nabovati P, et al. The Prevalence of Amblyopia and Its Determinants in a Population-based Study. Strabismus. 2017;25(4):176-83. DOI: https://doi.org/10.1080/09273972.2017.1391849

Mocanu V, Horhat R. Prevalence and Risk Factors of Amblyopia among Refractive Errors in an Eastern European Population. Medicina (Kaunas). 2018;54(1). DOI: https://doi.org/10.3390/medicina5401000619.

Aljohani S, Aldakhil S, Alrasheed SH, Tan QQ, Alshammeri S. The Clinical Characteristics of Amblyopia in Children Under 17 Years of Age in Qassim Region, Saudi Arabia. Clin Ophthalmol. 2022;16:2677-84. DOI: https://doi.org/10.2147/OPTH.S379550

Gabai A, Zeppieri M. Anisometropia. StatPearls. Treasure Island (FL): StatPearls Publishing; 2023. Available from: https://www.ncbi.nlm.nih.gov/books/NBK582146/

Guimaraes S, Soares A, Freitas C, et al. Amblyopia screening effectiveness at 3-4 years old: a cohort study. BMJ Open Ophthalmol. 2021;6(1):e000599. DOI: https://doi.org/10.1136/bmjophth-2020-000599

Blair K, Cibis G, Gulani AC. Amblyopia. StatPearls. Treasure Island (FL): StatPearls Publishing; 2023.Deneska RS. Severity of Amblyopia and Its Correlation with The Amount of Refractive Error. Ophthalmologica Indonesiana. 2015;41(1). DOI: https://doi.org/10.35749/journal.v41i1.14

Masters MP. Relative size of the eye and orbit: an evolutionary and craniofacial constraint model for examining the etiology and disparate incidence of juvenile-onset myopia in humans. Med Hypotheses. 2012;78(5):649-56. DOI: https://doi.org/10.1016/j.mehy.2012.02.002

Spillmann L. Stopping the rise of myopia in Asia. Graefes Arch Clin Exp Ophthalmol. 2020;258(5):943-59. DOI:

https://doi.org/10.1007/s00417-019-04555-0

Zou Y, Ulaganathan S, Read SA, Davis BA, Collins MJ. The Association between Childhood Myopia Prevalence and Environmental Factors in China: A Metaregression Analysis. Journal of Ophthalmology. 2020;2020:8736314. DOI: https://doi.org/10.1155/2020/8736314

Zhang X, Wang Y, Pan C, et al. Effect of Genetic-Environmental Interaction on Chinese Childhood Myopia. J Ophthalmol. 2020;2020:6308289. DOI: https://doi.org/10.1155/2020/6308289

Bamhane P, Singh P, Kumar K, et al. A prospective study of amblyopia and its risk factors in selected school going children of Bhopal region. Indian Journal of Clinical and Experimental Ophthalmology. 2022;8(1):24-9. DOI: https://doi.org/10.18231/j.ijceo.2022.006

Janti SS, Raja AM, Matheen A, Charanya C, Pandurangan R. A cross sectional study on prevalence of amblyopia in school going children. Journal of Evolution of medical and Dental Sciences. 2014;3:8561-5. DOI: https://doi.org/10.14260/jemds/2014/3086

Jarwal PN, Singh R. Evaluation of Amblyopia in School Going Children. Delhi Journal of Ophthalmology. 2020;30(3). DOI:

https://doi.org/10.14260/jemds/2014/3086

Asper L, Watt K, Khuu S. Optical treatment of amblyopia: a systematic review and meta-analysis. Clin Exp Optom. 2018;101(4):431-42. DOI: https://doi.org/10.1111/cxo.12657

Buckle M, Billington C, Shah P, Ferris JD. Treatment outcomes for amblyopia using PEDIG amblyopia protocols: a retrospective study of 877 cases. J aapos. 2019;23(2):98.e1-.e4. https://doi.org/10.1016/j.jaapos.2018.12.007

Papageorgiou E, Asproudis I, Maconachie G, Tsironi EE, Gottlob I. The treatment of amblyopia: current practice and emerging trends. Graefes Arch Clin Exp Ophthalmol. 2019;257(6):1061-78. DOI: https://doi.org/10.1007/s00417-019-04254-w

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Published

2024-06-15

How to Cite

Yulia, D. E., Barliana, J. D., Sitorus, R. S., Putri, M. R., & Soeharto, D. A. (2024). Clinical Characteristics of Children with Refrative Amblyopia at Cipto Mangunkusumo National Referral Hospital. Jurnal Profesi Medika : Jurnal Kedokteran Dan Kesehatan, 18(1), 21–29. https://doi.org/10.33533/jpm.v18i1.7582