Profile of Unilateral Cataract in Children With Congenital Rubella Syndrome
DOI:
https://doi.org/10.33533/jpm.v16i1.4283Keywords:
Cataract surgery, Congenital rubella syndrome, Contact lens, Microcornea, UnilateralAbstract
A congenital cataract is preventable blindness in children and is associated with intrauterine rubella infection known as congenital rubella syndrome (CRS), mostly found in developing countries. This study aims to describe the profile of unilateral cataracts in children with CRS, which are more difficult to manage than bilateral ones. As a retrospective study, we reviewed complete medical records of children with CRS and unilateral cataracts at Cipto Mangunkusumo hospital from 2017 to 2020. Fifteen patients were included, mostly male and from outside Jakarta.The mean age of onset was 2.9 months, while the average age at first presentation and surgery was 27.7 months and 29.1 months, respectively.No correlation was found between patients’ residential distance from the hospital towards duration between onset of symptoms and first presentation to the hospital. 100% and 66.7% of patients had leukocoria and microcornea as ocular manifestations. The majority of systemic manifestations are congenital heart disease.66.7% of children underwent cataract surgery without IOL implantation. Improvement of visual acuity postoperatively was observed in 13.3% of patients, and 66.7% of patients used contact lenses for visual rehabilitation. 60% of patients had posterior capsule opacity within six months of follow-up. The challenge of wearing contact lenses in children makes the risk of amblyopia even greaterReferences
Khokhar S, Jose CP, Sihota R, Midha N. Unilateral congenital cataract: Clinical profile and presentation. Journal of Pediatric Ophthalmology and Strabismus. 2018 Mar 1;55(2):107–12.
Shah MA, Shah SM, Shah AH, Pandya JS, Netralaya D. Visual outcome of cataract in pediatric age group: Does etiology have a role? European Journal of Ophthalmology. 2013 May 13;24(1):76–83.
Shah SK, Praveen MR, Vasavada AR, Vasavada VA, Carelli R, Trivedi RH, et al. Long-term longitudinal assessment of postoperative outcomes after congenital cataract surgery in children with congenital rubella syndrome. Journal of Cataract and Refractive Surgery. 2014 Dec 1;40(12):2091–8.
Vijayalakshmi P, Gaurav K, Samprathi A, Banushree R. Ocular Manifestations of Congenital Rubella Syndrome in a Developing C. 2002.
Nazme NI, Hussain M, Das AC. Congenital Rubella Syndrome-A Major Review and Update. Vol. 3, Delta Med Col J. Jul. 2015.
Atreya CD, Mohan KVK, Kulkarni S. Rubella virus and birth defects: Molecular insights into the viral teratogenesis at the cellular level. Vol. 70, Birth Defects Research Part A - Clinical and Molecular Teratology. 2004. p. 431–7.
Givens KT, Lee DA, Jones T, Ilstrup DM, Stein J. Congenital rubella syndrome: ophthalmic manifestations and associated systemic disorders [Internet]. Vol. 77, Britishgournal ofOphthalmology. 1993. Available from: http://bjo.bmj.com/
Koo EB, Gilbert AL, VanderVeen DK. Treatment of Amblyopia and Amblyopia Risk Factors Based on Current Evidence. Seminars in Ophthalmology. 2017 Jan 2;32(1):1–7.
Mohammadpour M, Shaabani A, Sahraian A, Momenaei B, Tayebi F, Bayat R, et al. Updates on managements of pediatric cataract. Vol. 31, Journal of Current Ophthalmology. Iranian Society of Ophthalmology; 2019. p. 118–26.
Retno LW, Radika Laboratorium Ilmu Kesehatan Mata Rumah Sakit Umum Saiful Anwar Malang KH. Katarak Pediatrik: Profil Klinik dan Faktor Determinan Hasil Terapi Pediatric Cataract: Clinical Profile and Outcomes Determinant.
Long J, Xiang D, Guo Z, Chen L, Chen F, Wang J, et al. Clinical Characteristics and Surgical Procedures for Children with Congenital Membranous Cataract. Journal of Ophthalmology. 2017;2017.
Chen YCE, Hu AC, Rosenbaum A, Spooner S, Weissman BA. Long-term results of early contact lens use in pediatric unilateral aphakia. Eye and Contact Lens. 2010 Jan;36(1):19–25.
A Randomized Clinical Trial Comparing Contact Lens With Intraocular Lens Correction of Monocular Aphakia During Infancy Grating Acuity and Adverse Events at Age 1 Year The Infant Aphakia Treatment Study Group* [Internet]. Available from: http://www.sph.emory
December 2002 Vijayalakshmi et al-Ocular Manifestations of Congenital Rubella Syndrome 307 Ocular Manifestations of Congenital Rubella Syndrome in a Developing Country.
Givens KT, Lee DA, Jones T, Ilstrup DM, Stein J. Congenital rubella syndrome: ophthalmic manifestations and associated systemic disorders [Internet]. Vol. 77, Britishgournal ofOphthalmology. 1993. Available from: http://bjo.bmj.com/
Duszak RS. Congenital rubella syndrome-major review. Vol. 80, Optometry. 2009. p. 36–43.
Li L, Wang Y, Xue C. Effect of timing of initial cataract surgery, compliance to amblyopia therapy on outcomes of secondary intraocular lens implantation in Chinese children: A retrospective case series. Journal of Ophthalmology. 2018;2018.
Vishwanath M, Cheong-Leen R, Taylor D, Russell-Eggitt I, Rahi J. Is early surgery for congenital cataract a risk factor for glaucoma? Vol. 88, British Journal of Ophthalmology. 2004. p. 905–10.
Magnusson G, Haargaard B, Basit S, Lundvall A, Nyström A, Rosensvärd A, et al. The Paediatric Cataract Register (PECARE): an overview of operated childhood cataract in Sweden and Denmark. Acta Ophthalmologica. 2018 Feb 1;96(1):51–5.
Vijayalakshmi P, Rajasundari TA, Prasad NM, Prakash SK, Narendran K, Ravindran M, et al. Prevalence of eye signs in congenital rubella syndrome in South India: A role for population screening. British Journal of Ophthalmology. 2007 Nov;91(11):1467–70.
Rajasundari TA, Sundaresan P, Vijayalakshmi P, Brown DWG, Jin L. Laboratory confirmation of congenital rubella syndrome in infants: An eye hospital based investigation. Journal of Medical Virology. 2008 Mar;80(3):536–46.
Mohammadpour M, Shaabani A, Sahraian A, Momenaei B, Tayebi F, Bayat R, et al. Updates on managements of pediatric cataract. Vol. 31, Journal of Current Ophthalmology. Iranian Society of Ophthalmology; 2019. p. 118–26.
Yu YS, Lee JH, Chang BL. Surgical management of congenital cataract associated with severe microphthalmos. 2000.
Repka MX. Visual rehabilitation in pediatric aphakia. Developments in Ophthalmology. 2016;57:49–68.
Cooksley G, Lacey J, Dymond MK, Sandeman S. Factors affecting posterior capsule opacification in the development of intraocular lens materials. Vol. 13, Pharmaceutics. MDPI; 2021.
Boengas S. Profil Kekeruhan Kapsul Lensa Posterior Pasca-Operasi Katarak Developmental. KELUWIH: Jurnal Kesehatan dan Kedokteran. 2020 Jun 30;1(2):53–61.
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