Vascular Risk Factor and Cognitive Impairment in Elderly


  • Rohmania Setiarini Department of Neurology, Faculty of Medicine, Islamic Al-Azhar University, Mataram NTB
  • Made Rika Anastasia Pratiwi Anatomy Department, Faculty of Medicine, Islamic Al-Azhar University, Mataram NTB
  • Mirzaulin Leonaviri Anatomy Department, Faculty of Medicine, Islamic Al-Azhar University, Mataram NTB



Cognitive Impairment, Diabetes Mellitus, Hypertension, Vascular Risk Factor


The elderly are more likely to experience cognitive impairment, especially those who have a vascular risk factor. The purpose of this study was to determine the relationship between vascular risk factor and cognitive impairment in the elderly. Observational research method with cross-sectional design consist of 79 participant in Tresna Werdha Puspa Karma Social Institution, Mataram from October to November 2021. The subjects were measured blood pressure, weight and height to obtain BMI, glucose level, and total cholesterol. Furthermore, each participant underwent a cognitive function test using Moca-INA. Data were analyzed by chi-square and logistic regression. Diabetes mellitus (p =0.09), hypertension (p =0.037), lower education (p =0,01) and hight blood pressure (p =0.036) were associated with poor cognitive function.


United Nation. World Population Ageing. Vol. 36, United Nations. 2017. 1119–1120 p.

Crimmins EM, Kim JK, Langa KM, Weir DR. Assessment of cognition using surveys and neuropsychological assessment: the Health and Retirement Study and the Aging, Demographics, and Memory Study. J Gerontol B Psychol Sci Soc Sci. 2011;66 Suppl 1:162–71.

Organización Mundial de la Salud. Risk Reduction Of Cognitive Decline And Dementia [Internet]. Who. 2019. 96 p. Available from:

Perdossi. Panduan Praktik Klinik Diagnosis dan Penatalaksanaan Demensia. 2015;

Peng Z, Jiang H, Wang X, Huang K, Zuo Y, Wu X, et al. The efficacy of cognitive training for elderly Chinese individuals with mild cognitive impairment. Biomed Res Int. 2019;2019(Mci).

Luchsinger JA. Type 2 diabetes and cognitive impairment: Linking mechanisms. J Alzheimer’s Dis. 2012;30(SUPPL.2):1–18.

Pais R, Ruano L, Carvalho OP, Barros H. Global cognitive impairment prevalence and incidence in community dwelling older adults—a systematic review. Geriatr. 2020;5(4):1–16.

Duan J, Lv Y Bin, Gao X, Zhou JH, Kraus VB, Zeng Y, et al. Association of cognitive impairment and elderly mortality: Differences between two cohorts ascertained 6-years apart in China. BMC Geriatr. 2020;20(1):1–9.

Petersen RC, Lopez O, Armstrong MJ, Getchius TSD, Ganguli M, Gloss D, et al. Practice guideline update summary: Mild cognitive impairment report of theguideline development, dissemination, and implementation. Neurology. 2018;90(3):126–35.

Yang J, Chon TY, Li G, Mallory MJ, Bublitz SE, Do A, et al. Tai Chi for patients with mild cognitive impairment: A protocol for a systematic review and meta-analysis of randomized controlled trials. Med (United States). 2019;98(40).

Patnode CD, Perdue LA, Rossom RC, Rushkin MC, Redmond N, Thomas RG, et al. Screening for Cognitive Impairment in Older Adults: An Evidence Update for the U.S. Preventive Services Task Force. Agency Healthc Res Qual [Internet]. 2020;(189):Report No.: 14-05198-EF-1. Available from:

Prasetyo, B.T, Lumempouw, S.F, Ramli, Y H. Nilai normal Montreal Cognitive Assessment versi Indonesia (MoCA-Ina). Neurona. 2011;29(1).

Wang Y, Song M, Yu L, Wang L, An C, Xun S, et al. Mild cognitive impairment: Vascular risk factors in community elderly in four cities of Hebei province, China. PLoS One. 2015;10(5):1–12.

Lakhani CM, Benjamin M. Davis, Glen F. Rall MJS. Neurovascular and cognitive dysfunction in hypertension: epidemiology, pathobiology and treatment. Physiol Behav. 2019;176(3):139–48.

Lin J, O´Connor E, Rossom R, Perdue L, Burda B, Thompson M, et al. Screening for cognitive impairment in older adults: a systematic review for the US Preventive Services Task Force (Structured abstract). Database Abstr Rev Eff [Internet]. 2013;(107):1–411. Available from:,DanaInfo=.awxyCrhhpHwvxL0wwPx6C,SSL+24354019

Pallangyo P, Mkojera ZS, Komba M, Mgopa LR, Bhalia S, Mayala H, et al. Burden and correlates of cognitive impairment among hypertensive patients in Tanzania: a cross-sectional study. BMC Neurol [Internet]. 2021;21(1):1–11. Available from:

Liu L, Hayden KM, May NS, Haring B, Liu Z, Henderson VW, et al. Association between blood pressure levels and cognitive impairment in older women: a prospective analysis of the Women’s Health Initiative Memory Study. Lancet Heal Longev [Internet]. 2022;3(1):e42–53. Available from:

Fitri FI, Rambe AS. Correlation between hypertension and cognitive function in elderly. IOP Conf Ser Earth Environ Sci. 2018;125(1).

Albu C, Padureanu V, Boldeanu M, Bumbea A, Enescu A, Albulescu D, et al. Vascular neurocognitive disorders and the vascular risk factors. J Mind Med Sci. 2018;5(1):7–15.

Canavan M, O’Donnell MJ. Hypertension and Cognitive Impairment: A Review of Mechanisms and Key Concepts. Front Neurol. 2022;13(February):1–9.

Pal K, Mukadam N, Petersen I, Cooper C. Mild cognitive impairment and progression to dementia in people with diabetes, prediabetes and metabolic syndrome: a systematic review and meta-analysis. Soc Psychiatry Psychiatr Epidemiol [Internet]. 2018;53(11):1149–60. Available from:

Aimen Malik , Mubariz Ahmed , Sarah Mansoor , Saima Ambreen , Basil Usman MS. Cognitive Impairment in Type 2 Diabetes Mellitus. 2022;14(2).

Naguib R, Soliman ES, Neimatallah FM, AlKhudhairy NS, ALGhamdi AM, Almosa RS, et al. Cognitive impairment among patients with diabetes in Saudi Arabia: a cross-sectional study. Middle East Curr Psychiatry. 2020;27(1).

Frison E, Proust-Lima C, Mangin JF, Habert MO, Bombois S, Ousset PJ, et al. Diabetes Mellitus and Cognition: Pathway Analysis in the MEMENTO Cohort. Neurology. 2021;97(8):e836–48.

Lindsay A. Zilliox, Krish Chadrasekaran, Justin Y. Kwan and JWR. Diabetes mellitus and cognitive impairment. Ter Arkh. 2016;91(10):112–8.

Li R, Wang TJ, Lyu PY, Liu Y, Chen WH, Fan MY, et al. Effects of Plasma Lipids and Statins on Cognitive Function. Chin Med J (Engl). 2018;131(4):471–6.

Shuangling Xiu , Qiuju Liao LS and PC. Risk factors for cognitive impairment in older people with diabetes: a community-based study. Ther Adv Vaccines. 2018;9(6):259–61.

Vintimilla R, Balasubramanian K, Hall J, Johnson L, O’Bryant S. Cardiovascular Risk Factors, Cognitive Dysfunction, and Mild Cognitive Impairment. Dement Geriatr Cogn Dis Extra. 2020;10(3):154–62.

Khade Y, Kumar AVS, Maruthy KN, Sasikala P. Does body mass index influence cognitive functions among young medical students? Clin Epidemiol Glob Heal [Internet]. 2021;12(August):100874. Available from:

Tzeyu L. Michaud, Mohammad Siahpush, Paraskevi A. Farazi, Jungyoon Kim, Fang Yu, Dejun Su, Daniel L. Murman. The Association between Body Mass Index, and Cognitive, Functional, and Behavioral Declines for Incident Dementia Tzeyu. Rev del Col Am Cardiol. 2018;72(23):2964–79.

Mun YS, Park HK, Kim J, Yeom J, Kim GH, Chun MY, et al. Association Between Body Mass Index and Cognitive Function in Mild Cognitive Impairment Regardless of APOE ε4 Status. Dement Neurocognitive Disord. 2022;21(1):30.

Karlsson IK, Gatz M, Arpawong TE, Dahl Aslan AK, Reynolds CA. The dynamic association between body mass index and cognition from midlife through late-life, and the effect of sex and genetic influences. Sci Rep [Internet]. 2021;11(1):1–15. Available from:


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How to Cite

Setiarini, R., Pratiwi, M. R. A., & Leonaviri, M. (2022). Vascular Risk Factor and Cognitive Impairment in Elderly. Jurnal Profesi Medika : Jurnal Kedokteran Dan Kesehatan, 16(2).