Determinant Factors of Low Cognitive, Motoric and Language Performance of HIV-Infected Children

Authors

  • Putu Indah Budiapsari FACULTY OF MEDICINE AND HELATH SCIENCES WARMADEWA UNIVERSITY
  • I Nyoman Supadma

DOI:

https://doi.org/10.33533/jpm.v16i1.4132

Keywords:

cognitive, motoric, language, HIV, children

Abstract

The Effects of HIV infection on children’s physical growth, psychological health, and neurodevelopment are essential. We aimed to find out the determinants factor of low cognitive, motoric and language performance of HIV-infected children. This study examined 68 HIV-infected children ranged 0-36 months. Cognitive, motoric and language were assessed using Cognitive Adaptive Test (CAT) and Clinical Linguistic and Auditory Milestone Scale (CLAMS) score which are components of of Capute Scale. Data was analyzed using cross tab, and significant Pearson chi-square (p < 0.05) was used to identify the determinant factors. The result showed that CD4 level, length of antiretroviral treatment, age, stage of HIV infection, socio economic status, and family income were determinant factors of low cognitive, motoric and language performance of HIV infected children. It can be concluded that cognitive, motoric and language were affected by CD4 level, length of antiretroviral treatment, age, stage of HIV infection, socio economic status, and family income.

 

Author Biography

Putu Indah Budiapsari, FACULTY OF MEDICINE AND HELATH SCIENCES WARMADEWA UNIVERSITY

PARASITOLOGY, TRAVEL HELATH, INFECTIOUS DISEASE

References

Sherr et al. 2014. Developmental challenges in HIV infected children—An updated systematic review. Children and Youth Services Review. Vol. 45, pp 74–89

World Health Organization. 2020. Paediatric HIV and treatment of children living with HIVhttps://www.who.int/hiv/1/en/. Accessed April 30th 2020.

Andrade ASA, Deutsch R, Celano SA, Duarte NA, Marcotte TA, Umlauf A. Relationships among neurocognitive status, medication adherence measured by pharmacy refill records, and virologic suppression in HIV-infected patients. Journal Acquired Immune Deficiency Syndrome. 2012;62:282-92.

Mwaba SOC, Ngoma MS, Kusanthan T and Menon JA. The Effect of HIV on Developmental Milestones in Children. Journal of AIDS & Clinical Research. 2016. Volume 6 Issue 7 1000482. DOI: 10.4172/2155-6113.1000482

McHenry MS, McAteer CI, Oyungu E. Neurodevelopment in Young Children Born to HIV-Infected Mothers: A Meta-analysis. PEDIATRICS Volume 141, number 2, February 2018:e20172888. DOI: 10.1542/peds.2017-2888

Bello AI, Jonathan NA Quartey and Louisa A Appiah. Screening for developmental delay among children attending a rural community welfare clinic in Ghana. BMC Pediatrics 2013, 13:119 http://www.biomedcentral.com/1471-2431/13/119

Kube D David A., William M. Wilson, MA, Mario C. Petersen, and Frederick B. Palmer CAT/CLAMS: Its Use in Detecting Early Childhood Cognitive Impairment Pediatric Neurology. 2018. Vol. 23 No. 3.pp 208-215, doi https://doi.org/10.1016/S0887-8994(00)00191-0

Whitehead N, Potterton J, Coovadia A. The Neurodevelopment of HIV-infected Infants on HAART compared to HIV-exposed but uninfected infants. AIDS Care. 2014;26:497-504.

Nakasuja N, Allebeck P, Agren H, Musisi S, Katabira E. Cognitive dysfunction among HIV positive and HIV negative patients with psychosis in Uganda. PLoS One. 2012;7:e44415. doi:10.1371/journal.pone.0044415

Bunyasi E K, David John Coetzee. Relationship between socioeconomic status and HIV infection: findings from a survey in the Free State and Western Cape Provinces of South Africa. BMJ Open. 2017;7: e016232. doi:10.1136/bmjopen-2017-016232

Ngoma MS, Hunter JA, Harper JA, et al. 2014. Cognitive and language outcomes in HIV-uninfected infants exposed to combined antiretroviral therapy in utero and through extended breast-feeding. AIDS. 28 (Suppl 3):S323–S330 DOI:10.1097/QAD.0000000000000357

Violari A, Mark F. Cotton, Louise Kuhn, Diana B. Schramm. 2019. A child with perinatal HIV infection and long-term sustained virological control following antiretroviral treatment cessation. Nature Communications. 10:412 doi.org/10.1038/s41467-019-08311-0

Weber V, Daniel Radeloff, Bianca Reimersa, Emilia Salzmann-Manrique, Peter Bader, MD, P. Neurocognitive development in HIV-positive children is correlated with plasma viral loads in early childhood. Medicine (2017) 96:23. Doi.org/10.1099/MD.0000000000006867

Redmond SM, Tzy-Jyun Yao,2 Jonathan S. Russell Longitudinal Evaluation of Language Impairment in Youth With Perinatally Acquired Human Immunodeficiency Virus (HIV) and Youth With Perinatal HIV Exposure. Journal of the Pediatric Infectious Diseases Society, Vol. 5, Suppl 1, pp. S33–S40, 2016. DOI:10.1093/jpids/piw045

Walker S.Y., Pierre R.B., Christie C.D.C., Chang S.M. Neurocognitive function in HIV-positive children in a developing country. International Journal of Infectious Diseases 17 (2013) e862–e867.doi.org/10.1016/j.ijid.2013.02.014

Rice ML, Buchanan AL, Sibery GK, Malee KM, Zeldow B, Frederick T. Language impairment in children perinatally infected with HIV compared to child who were HIV-exposed and uninfected. Journal Dev Behaviour Padiatric. 2012;33:112-23. doi:10.1097/DBP.0b013e318241ed23.

Ravindran OS, Mrudula P. Rani1, G. Priya. 2014. Cognitive Deficits in HIV Infected Children. Indian Journal of Psychological Medicine | Jul - Sep 2014 | Vol 36 | Issue 3, pp. 255-259

Widyadharma E, Satiti S, Nuradyo D, Setyopranoto A,Wijayanti. 2017. The Difference of CD4 Count Between HIV Positive Patients With Cognitive Decline and Without Cognitive Decline. Biomedical & Pharmacology Journal Vol. 10(2), 969-978.

Supadma N, Budiapsari, PI, Wati KDK, Artana IWD. 2020. Correlation of Capute Scores with CD4 Count among Human Immunodeficiency Virus-infected Children in Sanglah Hospital, Bali, Indonesia. Open Access Macedonian Journal of Medical Sciences. Vol 8(B):45-48.

Ranjitkar S, Hysing M, Kvestad I, Shrestha M, Ulak M, Shilpakar JS, Sintakala R, Chandyo RK, Shrestha L and Strand TA (2019) Determinants of Cognitive Development in the Early Life of Children in Bhaktapur, Nepal. Front. Psychol. 10:2739. doi: 10.3389/fpsyg.2019.02739

Cohen S, Jacqueline A. ter Stege, Gert J. Geurtsen, Henriette J. Scherpbier, Taco W. Kuijpers, Peter Reiss, Ben Schmand, and Dasja Pajkrt. 2015. Poorer Cognitive Performance in Perinatally HIV-Infected Children Versus Healthy Socioeconomically Matched Controls. HIV/AIDS. Clinical Infectious Diseases. Vol. 60(7):1111–9

Khandelwal N, Mandliya J, Nigam K, Patil V, Mathur A, Pathak A (2020) Determinants of motor, language, cognitive, and global developmental delay in children with complicated severe acute malnutrition at the time of discharge: An observational study from Central India. PLoS ONE 15(6): e0233949. https://doi.org/10.1371/ journal.pone.0233949

Ruel TD, Michael J. Boivin, Hannah E. Boal, Paul Bangirana, Edwin Charlebois, Diane V. Havlir, Philip J. Rosenthal, Grant Dorsey, Jane Achan, Carolyne Akello, Moses R. Kamya, and Wong JK. Neurocognitive and Motor Deficits in HIV-Infected Ugandan Children With High CD4 Cell Counts. Clinical Infectious Diseases 2012;54(7):1001–9

Blokhuis C, Neeltje A Kootstra, Matthan wA Caan, Dasja Pajkrt. Neurodevelopmental delay in pediatric HIV/AIDS: current perspectives. Neurobehavioral HIV Medicine 2016:7 1–13

Wedderburn CJ, Shunmay Yeung, Andrea M Rehman, Jacob A M Stadler, Raymond T Nhapi, Whitney Barnett, Landon Myer, Diana M Gibb, Heather J Zar, Dan J Stein, Kirsten A Donald. Neurodevelopment of HIV-exposed uninfected children in South Africa: outcomes from an observational birth cohort study. Lancet Child Adolesc Health. 2019; 3: 803–13

Sania A, Sudfeld CR, Danaei G, et al. Early life risk factors of motor, cognitive and language development: a pooled analysis of studies from low/middle-income countries. BMJ Open 2019;9:e026449. doi:10.1136/ bmjopen-2018-026449

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Published

2022-06-16

How to Cite

Budiapsari, P. I., & Supadma, I. N. (2022). Determinant Factors of Low Cognitive, Motoric and Language Performance of HIV-Infected Children. Jurnal Profesi Medika : Jurnal Kedokteran Dan Kesehatan, 16(1). https://doi.org/10.33533/jpm.v16i1.4132