RETN Gene Single Nucleotide Polymorphism Profile on Triglyceride-Glucose Index as Insulin Resistance Proxy Among Cohort Population of Non-Communicable Diseases in Bogor

Frans Dany; Uly Alfi Nikmah; Ratih Rinendyaputri; Fitrah Ernawati; Dewi Kristanti; Fifi Retiaty

doi:10.33533/jpm.v16i1.4342

Authors

Frans Dany Pusat Riset Biomedis, Organisasi Riset Kesehatan, Badan Riset dan Inovasi Nasional (BRIN), Gedung B.J. Habibie Jalan M.H. Thamrin Nomor 8, Jakarta Pusat 10340 http://orcid.org/0000-0003-1412-5894
Uly Alfi Nikmah Pusat Riset Biomedis, Organisasi Riset Kesehatan, Badan Riset dan Inovasi Nasional (BRIN), Gedung B.J. Habibie Jalan M.H. Thamrin Nomor 8, Jakarta Pusat 10340
Ratih Rinendyaputri Pusat Riset Biomedis, Organisasi Riset Kesehatan, Badan Riset dan Inovasi Nasional (BRIN), Gedung B.J. Habibie Jalan M.H. Thamrin Nomor 8, Jakarta Pusat 10340
Fitrah Ernawati Pusat Riset Kesehatan Masyarakat dan Gizi, Organisasi Riset Kesehatan, Badan Riset dan Inovasi Nasional (BRIN), Gedung B.J. Habibie Jalan M.H. Thamrin Nomor 8, Jakarta Pusat 10340
Dewi Kristanti Badan Kebijakan Pembangunan Kesehatan (BKPK), Kementerian Kesehatan RI, Jln Percetakan Negara no 29, Jakarta Pusat 10560
Fifi Retiaty Pusat Riset Kesehatan Masyarakat dan Gizi, Organisasi Riset Kesehatan, Badan Riset dan Inovasi Nasional (BRIN), Gedung B.J. Habibie Jalan M.H. Thamrin Nomor 8, Jakarta Pusat 10340

DOI:

https://doi.org/10.33533/jpm.v16i1.4342

Keywords:

Cohort, Diabetes Melitus, Resistin, Single Nucleotide Polymorphism, Triglyceride-Glucose index

Abstract

Genetic factors such as single nucleotide polymorphisms (SNPs) are thought to contribute to the increasing incidence of diabetes mellitus (DM) through insulin resistance. SNPs in the RETN (resistin) gene encoding the resistin protein have been reported to play a role in causing abnormalities in blood glucose and lipid metabolism. Still, studies related to this have rarely been explored in cohort population models. This study aimed to evaluate the relationship of resistin gene SNPs to the trend of the triglyceride-glucose index (TyG) as a proxy for insulin resistance. The data were obtained from the results of the biomedical laboratory examination among participants of a cohort study in the Kebon Kalapa subdistrict, Bogor, every odd year period between 2015-2021 and from RETN genotyping (rs3745367). The generalized linear model (GLM) repeated measurement technique was used with the TyG index value as the dependent variable. The results of the GLM analysis showed that although there was a significant difference in the trend of the TyG index between the observation periods [F(2,87, 1671,1)=41,10, p-value <0.001], that’s not the case for RETN gene SNP [F(5,73, 1671,1) = 1.09, p-value = 0.367]. However, the multivariate test results suggested the association of these SNPs with age and DM status [F(4, 583)=2.48, p-value = 0.043]. In conclusion, RETN gene SNPs may require interaction with other factors or genes to induce insulin resistance or act by indirect glucose–fatty acid metabolic cycle mechanisms.

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