Factors Associated with BCG Scar of Pediatric Tuberculosis Patients at Pisangan and East Ciputat Community Health Centers

Farsida Farsida; Ayu Farah Syifa; Azka Zifa Tanama

doi:10.33533/jpm.v16i1.4341

Authors

Farsida Farsida
Ayu Farah Syifa Program Studi Pendidikan Dokter, Fakultas Kedokteran dan Kesehatan, Universitas Muhammadiyah Jakarta, Jl. KH. Ahmad Dahlan Ciputat Cirendeu 15419
Azka Zifa Tanama

DOI:

https://doi.org/10.33533/jpm.v16i1.4341

Keywords:

Child TB, Contact History, Scar BCG

Abstract

Tuberculosis (TB) is the most common cause of death in children. Prevention of TB through Bacille Calmette–Guérin (BCG) vaccination is an action to produce immunity against TB disease. After vaccination, a scar forms from the boil, which indicates a successful vaccination. This study aims to determine the factors associated with BCG Scar in pediatric TB patients. A cross-sectional design was conducted at the Pisangan and East Ciputat Community Health Centers in January-September 2020. Data collection using medical records and telephone interviews on 35 samples was taken using the probability sampling technique, simple random sampling. With inclusion criteria for pediatric TB patients (0-18 years) and exclusion criteria that do not include telephone numbers and addresses. Bivariate analysis was used with the chi-square test. The results showed a significant relationship between contact history and BCG scars in pediatric TB patients. Age, gender, nutritional status, exclusive breastfeeding, immunization, mother's education, parent's occupation, family income, and smoking history were not significantly related to BCG scar. Contact history related to BCG scar. Parents should pay more attention to and protect their children from the people around them to cut off the possibility of contact with TB sufferers even though the child has been vaccinated.

References

WHO. Global Tuberculosis Report 2020. 2020.

Kemenkes RI. Profil Kesehatan Indonesia Tahun 2019. Jakarta: Kementerian Kesehatan RI; 2020.

Ikatan Dokter Anak Indonesia (IDAI). Skar BCG. Jakarta: Ikatan Dokter Anak Indonesia (IDAI); 2016.

Benn CS, Roth A, Garly M-L, Fisker AB, Schaltz-Buchholzer F, Timmermann A, et al. BCG scarring and improved child survival: a combined analysis of studies of BCG scarring. J Intern Med. 2020;288(6):614–624.

Farsida, Hatta M, Patellongi I, Prihantono, Shabariyah R, Larasati Laras RA, et al. The correlation of Foxp3 + gene and regulatory T cells with scar BCG formation among children with Tuberculosis. J Clin Tuberc other Mycobact Dis. 2020;21:1–7.

Funch KM, Thysen SM, Rodrigues A, Martins CL, Aaby P, Benn CS, et al. Determinants of BCG scarification among children in rural Guinea-Bissau: A prospective cohort study. Hum Vaccines Immunother. 2018;14(10) :2434–1432.

Rosandali F, Aziz R, Suharti N. Hubungan antara Pembentukan Scar Vaksin BCG dan Kejadian Infeksi Tuberkulosis. J Kesehat Andalas. 2016;5(2):381–384.

Sugiyono. Metode Penelitian Kuantitatif dan Kualitatif. Jakarta: Alfabeta; 2012.

Brajadenta GS, Laksana ASD, Peramiarti IDSAP. Faktor Risiko Tuberkulosis Paru Anak: Studi pada Balai Kesehatan Paru Masyarakat (BKPM) Purwokerto. Str J Ilm Kesehat. 2018;7(2):1–6.

Rahajoe NN, Supriyatno B, Setyanto DB. Buku Ajar Respirologi Anak. 4th ed. Jakarta: Ikatan Dokter Anak Indonesia; 2018.

Farsida, Shabariah R, Hatta M, Patellongi I, Prihantono, Nasrum Massi M, et al. Relationship between expression mRNA gene Treg, Treg, CD4+, and CD8+ protein levels with TST in tuberculosis children: A nested case-control. Ann Med Surg. 2020;61:44–47.

Kemenkes RI. TB Anak. Jakarta: Kementerian Kesehatan RI; 2019.

Rakhmawati FJ, Yulianti AB, Widayanti. Angka Kejadian Tuberkulosis Paru pada Anak dengan Imunisasi BCG di RSUD Al-Ihsan Bandung Bulan Januari – Juni 2019. J Integr Kesehat dan Sains. 2020;2(2):114–117.

Pradani SA, Kundarto W. Evaluasi Ketepatan Obat dan Dosis Obat Anti Tuberkulosis pada Pasien Anak Di Instalasi Rawat Jalan RSUD Dr. Moewardi Surakarta Periode 2016-2017. J Pharm Sci Clin Res. 2018;3(2):93–103.

Permatasari TO, Trijati MH. Karakteristik Individu yang Berhubungan dengan Kejadian Tuberkulosis Paru Balita di Balai Kesehatan Paru Masyarakat (BKPM) Kota Cirebon. Tunas Med J Kedokt Kesehat. 2014;1(2):1–8.

Nelson LJ, Wells CD. Global epidemiology of childhood tuberculosis. Int J Tuberc lung Dis. 2004;8(5):636–647.

Ridwan H, Rosita Y, Sahfitri A. Faktor Risiko yang Berhubungan dengan Kejadian Tuberkulosis di RSK Paru Palembang Periode Januari-Desember 2010. Syifa’MEDIKA. 2012;2(2):98–107.

Dotulong JFJ, Sapulete MR, Kandou GD. Hubungan Faktor Risiko Umur, Jenis Kelamin Dan Kepadatan Hunian Dengan Kejadian Penyakit Tb Paru Di Desa Wori Kecamatan Wori. J Kedokt Komunitas Dan Trop. 2015;3(2):57–65.

Rakhmawati W, Fatimah S, Trisyani M, Nurhidayah I. Faktor-Faktor yang Berhubungan dengan Kejadian Tuberkulosis pada Anak di Kecamatan Ngamprah Kabupaten Bandung Barat. Maj Keperawatan Unpad. 2011;13(1).

Putra IA, Amelia. Profil Tuberkulosis Pada Anak di Instalasi Rawat Jalan RSUD Raden Mattaher Jambi. Jambi Med J. 2013;1:51–60.

Nurwitasari A, Wahyuni CU. Pengaruh Status Gizi dan Riwayat Kontak terhadap Kejadian Tuberkulosis Anak di Kabupaten Jember. Berk Epidemiol. 2015;3(2):158–69.

Noviarisa N, Yani FF, Basir D. Tren Kasus Tuberkulosis Anak di RSUP Dr. M. Djamil Padang Tahun 2014-2016. J Kesehat Andalas. 2019;8 (Supplement 1):36–41.

Birk NM, Nissen TN, Ladekarl M, Zingmark V, Kjærgaard J, Jensen TM, et al. The association between Bacillus Calmette-Guérin vaccination (1331 SSI) skin reaction and subsequent scar development in infants. BMC Infect Dis. 2017;17(1):1–8.

Li J, Zhao A, Tang J, Wang G, Shi Y, Zhan L, et al. Tuberculosis vaccine development: from classic to clinical candidates. Eur J Clin Microbiol Infect Dis. 2020;39(8):1405–25.

Tabatabaei H. Newborn BCG Vaccinations: Scar Formation and Tuberculin Conversion Rates: A Retrospective Study. Am J Pediatr. 2019;5(1):1–6.

Putri RF, Sulastri D, Lestari Y. Faktor-Faktor yang Berhubungan dengan Status Gizi Anak Balita di Wilayah Kerja Puskesmas Nanggalo Padang. J Kesehat Andalas. 2015;4(1):254–261.

Fauza R. Pengaruh Status Gizi Terhadap Kejadian Tb Paru Pada Anak Usia 1-5 Tahun Yang Telah Mendapatkan Imunisasi Bcg Di Rsu Imelda Pekerja Indonesia Tahun 2016. J Ilm Kebidanan Imelda. 2019;5(2):68–73.

Riani RES, Machmud PB. Kasus Kontrol Hubungan Imunisasi BCG dengan kejadian TB Paru pada anak tahun 2015-2016. Sari Pediatr. 2018;19(6):321–7.

Manalu HSP. Faktor-Faktor Yang Mempengaruhi Kejadian TB Paru Dan Upaya Penanggulangannya. J Ekol Kesehat. 2010;9(4):1340–1346.

Samuel B, Volkmann T, Cornelius S, Mukhopadhay S, MejoJose, Mitra K, et al. Relationship between Nutritional Support and Tuberculosis Treatment Outcomes in West Bengal, India. J Tuberc Res. 2016;4(4):213–219.

Puspitasari R, Saraswati L, Hestiningsih R. Faktor Yang Berhubungan Dengan Kejadian Tuberkulosis Pada Anak (Studi Di Balai Kesehatan Paru Masyarakat Semarang). J Kesehat Masy. 2015;3(1):191–197.

Lalor MK, Ben‐Smith A, Gorak‐Stolinska P, Weir RE, Floyd S, Blitz R, et al. Population Differences in Immune Responses to Bacille Calmette‐Guérin Vaccination in Infancy. J Infect Dis. 2009 Mar;199(6):795–800.

Dhanawade SS, Kumbhar SG, Gore AD, Patil VN. Scar formation and tuberculin conversion following BCG vaccination in infants: A prospective cohort study. J Fam Med Prim care. 2015;4(3):384–387.

Atimati A, Osarogiagbon O. Prevalence of BCG scar among BCG-vaccinated children in a southern Nigeria tertiary hospital. Niger J Paediatr. 2014;41(3):229–233.

Amaruddin AI, Wahyuni S, Hamid F, Chalid MT, Yazdanbakhsh M, Sartono E. BCG scar, socioeconomic and nutritional status: a study of newborns in an urban area of Makassar, Indonesia. Trop Med Int Heal. 2019;24(6):736–746.

Roth A, Gustafson P, Nhaga A, Djana Q, Poulsen A, Garly ML, et al. BCG vaccination scar associated with better childhood survival in Guinea-Bissau. Int J Epidemiol. 2005;34(3):540–575.