Association Between High Density Lipoprotein Level With Degree Of Stenosis In Coronary Artery Disease

Arrizki Azka Pratama; Saugi Abduh; Siti Thomas Zulaikhah

doi:10.33533/jpm.v15i2.2964

Authors

Arrizki Azka Pratama Universitas Islam Sultan Agung Semarang (UNISSULA)
Saugi Abduh Program Pascasarjana, Fakultas Kedokteran (UNISSULA), Semarang
Siti Thomas Zulaikhah Departemen Penyakit Dalam, Fakultas Kedokteran (UNISSULA), Semarang

DOI:

https://doi.org/10.33533/jpm.v15i2.2964

Keywords:

HDL Level, Coronary Artery Disease, Degree of Stenosis, Significant-Non Significant score

Abstract

Coronary Artery Disease (CAD) can be prevented by early detection and control of risk factors. This study aimed to determine the relationship of High Density Lipoprotein (HDL) levels with stenosis levels based on Significant Non-Significant angiography in CAD patients. Observational research method with cross-sectional design from secondary data at RSI Sultan Agung Semarang in January 2016 - October 2018, 363 respondents met the inclusion and exclusion criteria. Data were analyzed by Spearman test and logistic regression. In low HDL, significant stenosis was found to be 80.5% and non-significant 19.5%, significant HDL was found with significant stenosis 67.0% and non-significant 33.0%, whereas in high HDL, all (100%) with significant stenosis. The results with the Spearman test obtained p = 0.022. In the multivariate analysis of sex as the predominant variable (p=0,000; PR=4.743; 95%CI=1.496-4.109). age (p = 0.013; PR = 3.48; 95% CI = 1.24- 6.13), hypertension (p = 0.044; PR = 1.79; 95% CI = 1.10-3.17). There was a significant relationship between HDL levels and significant stenosis levels based on significant non-angiography in CAD patients and after being analyzed together with the disrupting variables as sex the most influential factors.

Author Biography

Arrizki Azka Pratama, Universitas Islam Sultan Agung Semarang (UNISSULA)

Departmen of Public Health

References

AHA. Heart Disease and Stroke Statistics 2017 At-a-Gl.

Sanchis-gomar, Fabian, Carme Perez-quilis, Roman Leischik, and Alejandro Lucia. “Epidemiology of Coronary Heart Disease and Acute Coronary Syndrome.” 2016; 4(13): 1-12.

Badan Penelitian dan Pengembangan Kesehatan. (2013). Riset Kesehatan Dasar (RISKESDAS) 2013. Laporan Nasional 2013, 1–384. https://doi.org/1 Desember 2013.

Ghani, Lannywati et al. “Faktor Risiko Dominan Penyakit Jantung Koroner Di Indonesia.” 2016; 153–64.

Rahman A. Artikel Penelitian Faktor-Faktor Risiko Mayor Aterosklerosis Pada Berbagai Penyakit Aterosklerosis Di RSUP Dr. Kariadi Semarang. Faculty of Medicine Diponegoro University. 2012.

Mackay J, Mensah GA. The Atlas of Heart Disease and Stroke. Geneva WHO, 2005; 30-49.

Bull E, Morrell J. Simple Guides Kolesterol. Edisi ke-1. Jakata: Erlangga, 2007; 3-22.

Natarajan, Pradeep, Kausik K. Ray, and Christopher P. Cannon. "High-Density Lipoprotein and Coronary Heart Disease. Current and Future Therapies." Journal of the American College of Cardiology. 2010; 55(13): 1283–99.

Neeland IJ, Patel, R.S., Eshtehardi, P., Dhawan, S. Coronary Angiographic Scoring System. Am Heart Journal.2012; 164(4): 547-552.

Saffar HB, Al Ghizzi, H.J., Muhammed, S.M.The Ankle Brachial Pressure Index As A Predictor of Coronary Artery Disease Severity. Journal Fac Med Baghdad. 2009; pp 254-258.

Gepner, A. D., Piper, M. E., Johnson, H. M., Fiore, M. C., Baker, T. B., & Stein, J. H. Effects of smoking and smoking cessation on lipids and lipoproteins: Outcomes from a randomized clinical trial. American Heart Journal. 2011; 161(1), 145–151. https://doi.org/ 10.1016/j.ahj.2010.09.023.

Dahlan, MS. Statistik untuk Kedokteran dan Kesehatan. Epidemiologi Indonesia. Jakarta. 2014.

Suherwin. Hubungan Usia, Jenis Kelamin Dan Riwayat Penyakit Dengan Kejadian Penyakit Jantung Koroner Di Instalasi Gawat Darurat Rumahsakit Tk.Ii Dr. Ak. Gani Palembang. Jurnal Aisyiyah Medika. Palembang. 2018.

Rahayu, M. S. Hubungan Indeks Massa Tubuh dengan Jantung Koroner Di Rumah Sakit Umum Cut Meutia, 2015; 9–16.

Ridwan, M., Setiawan, A.. Hubungan Tingkat Adiksi Merokok Dengan Derajat Keparahan Aterosklerosis Pada Pasien Penyakit Jantung Koroner. Jurnal Kedokteran Diponegoro. 2016; 5 (4).