The Correlation Between Adiponectin Levels With C-Reactive Protein in Adult Obese Non-Diabetic Among Staffs of DR. M. Djamil Hospital Padang
DOI:
https://doi.org/10.33533/jpm.v15i1.2719Keywords:
Adiponectin, Chronic low grade inflammation, C-reactive protein, Obesity.Abstract
The adiponectin and C-reactive protein (CRP) are markers of chronic low-grade inflammation related to obesity. This study aims to determine a correlation between adiponectin level and CRP level in adult obese individuals. This study was analyzed with a cross-sectional design of 55 subjects at Dr. M Jamil Central Hospital Padang from January to September 2019. The subjects included were type 1 obese (25≤BMI≤29.9 kg/m2) and type 2 obese (BMI 30.0 kg/m2). Enzyme-linked immunoassay (ELISA) was used to measure adiponectin and High Sensitivity C-Reactive Protein (Hs-CRP) levels. Univariate statistical analysis is processed and presented in distribution, frequency, mean (standard deviation), median (minimum-maximum value). Bivariate data were analyzed using the Pearson correlation test, significant if p<0.05. The study consists of 16 males and 39 females. The mean age was 35 years old (the range 23 to 57 years old), the mean BMI was 30.8 (4.5) kg/m2. This study consists of 28 subjects, type 1 obese and 27 types II obese. The mean adiponectin level in type 2 obese is lower than in type 2 obese groups. The mean CRP levels are high in all populations. Pearson ln-adiponectin and CRP correlation test in the entire population: r =-0.105 (p=0.444).
References
Abraham PA, Attipoe S, Kazman JB, Zeno SA, Poth M, Deuster PA. Role Of Plasma Adiponectin / C-Reactive Protein Ratio In Obesity And Type 2 Diabetes Among African Americans. Afri Health Sci.2017;17(1):99-107.
Asghar A, Sheikh N. Role Of Immune Cells In Obesity Induced Low Grade Inflammation And Insulin Resistance. Cellular Immunology. 2017; 315:18–26.
Ellulu MS, Patimah I, Khaza'ai H, Rahmat A, Abed Y. Obesity And Inflammation: The Linking Mechanism And The Complications. Arch Med Sci. 2017;4:851–863.
Susantiningsih T, Mustofa S. Ekspresi IL-6 Dan TNF-α Pada Obesitas. JK Unila. 2018;2(2):1-7.
Jain V, Kumar A, Agarwala A, Vikram N, Ramakrishnan L. Adiponectin, Interleukin-6 And High-Sensitivity C-Reactive Protein Levels In Overweight/Obese Indian Children. Indian Pediatrics. 2017:(54), 858-861.
Regina F, Tirtamulia K, Warouw SM. Adiponectin And Highly Sensitive C-Reactive Protein, Levels In Obese Children Aged 9 To 15 Years. Paediatr Indones. 2011;51(1):7-11.
Li J, Liao C, Su H, Peng Q, Zhang Z, Yan S,Yang Q. The Relationship Among Adiponectin, High Sensitive C Reactive Protein And Triacylglycerol Level In Healthy Young Persons, Lipids In Health And Disease. 2011;10(109): 1-5.
Goksen D, Levent E, Kar S, Özen S, D S. Serum Adiponectin And hsCRP Levels And Non-Invasive Radiological Methods In The Early Diagnosis Of Cardiovascular System Complications In Children And Adolescents With Type 1 Diabetes Mellitus. J Clin Res Pediatr Endocrinol 2013;5(3):174-181
Al-Hamodi Z, AL-Habori M, Al-Meeri, Saif-Ali R. Association Of Adipokines, Leptin/Adiponectin Ratio And C-Reactive Protein With Obesity And Type 2 Diabetes Mellitus. Diabetol Metab Syndr 2014;6(99):1-8.
Balsan GA, Vieira JL, Oliveira AM, Portal VL. Relationship Between Adiponectin, Obesity And Insulin Resistance. Rev Assoc Med Brass. 2015;61(1):72–80.
Fang H, Judd RL. Adiponectin Regulation And Function. Comprehensive Physiology, 2018;8: 1031–1063.
Yu N, Ruan Y, Gao X, Sun J. Systematic Review And Meta-Analysis Of Randomized, Controlled Trials On The Effect Of Exercise On Serum Leptin And Adiponectin In Overweight And Obese Individuals. Horm Metab Res. 2017;49(03):164–173.
Kawamoto R, Kusunoki T, Abe M, Kohara K, & Miki T. An Association Between Body Mass Index And High-Sensitivity C-Reactive Protein Concentrations Is Influenced By Age In Community-Dwelling Persons. An International Journal Of Biochemistry And Laboratory Medicine. 2013: 50(5), 457–464.
Ahonen TM, Saltevo J. T., Kautiainen, H. J., Kumpusalo, E. A., & Vanhala, M. J. The Association Of Adiponectin And Low-Grade Inflammation With The Course Of Metabolic Syndrome. Nutrition, Metabolism And Cardiovascular Diseases. 2012. 22(3), 285–291. Doi:10.1016/J.Numecd.2010.07.001
Delongui F, Kallaur AP, Oliveira SR, Bonametti AM, Grion CMC, Morimoto HK, et al., Serum Levels Of High Sensitive C Reactive Protein In Healthy Adults From Southern Brazil. Journal Of Clinical Laboratory Analysis. 2013; 27(3):207–210.
Choi J, Joseph L, & Pilote L. Obesity And C-Reactive Protein In Various Populations: A Systematic Review And Meta-Analysis. Obesity Reviews, 2012:14(3):232–244.
Sproston NR, & Ashworth JJ. Role of C-Reactive Protein at Sites of Inflammation and Infection. Frontiers in Immunology. 2018;9(757):1-11.
Ding D, Wang M, Su D, Hong C, Li X, Yang Y, Zang Y, Hu G, Ling W. Body Mass Index, High Sensitity C-Reactive Protein And Mortality In Chinese With Coronary Artery Disease. Plose One. 2015;10(8):1-11.
Conroy SM, Chai W, Lim U, Franke AA, Cooney RV,& Maskarinec G. Leptin, Adiponectin, and Obesity among Caucasian and Asian Women. Mediators of Inflammation.2011; 1–7.
Amudi T, Pandelaki K, & Palar S. Hubungan antara hs-CRP , Adiponektin, Fetuin A terhadap Resistensi Insulin pada Pria Dewasa Muda dengan Obesitas Sentral. e-CliniC. 2021;9(1):231-237
Diagnostics Biochem Canada, Adiponectin Elisa, 2018a; Ref: CAN-APN-5000: 1-2.
Diagnostics Biochem Canada. High Sensitivity C-Reactive Protein (CRP) Elisa.2018b; Ref: CAN CRP-4360 :1-2.
Dahlan MS. Hipotesis Korelatif, Dalam Statistik Untuk Kedokteran Dan Kesehatan. Seri 1.Jakarta: Sagung Seto. 2014; 6: 223-24.
Engin, A. Adiponectin-Resistance in Obesity. Advances in Experimental Medicine and Biology. Springer International Publishing. 2017;18.415–441.
Pangestu YM, Sarah M, Warouw S, Tatura SN. Hubungan kadar 25-hydroksivitamin D dan high molecular weight adiponectin pada remaja obes. Sari Pediatri; 17(1):64-70.
El husseny MWA, Mamdouh M, Shaban S, Ibrahim Abushouk A, Zaki MMM, Ahmed OM, & Abdel-Daim MM. Adipokines: Potential Therapeutic Targets for Vascular Dysfunction in Type II Diabetes Mellitus and Obesity. Journal of Diabetes Research, 2017, 1–11.
Ebron K, Andersen C J, Aguilar D, Blesso C N, Barona J, Dugan CE, et al. A Larger Body Mass Index Is Associated With Increased Atherogenic Dyslipidemia, Insulin Resistance, And Low-Grade Inflammation In Individuals With Metabolic Syndrome. Metabolic Syndrome And Related Disorders. 2015;13(10):458–464.
Ahmed B, Sultana R, & Greene MW. Adipose Tissue and Insulin Resistance in Obese. Biomedicine & Pharmacotherapy. 20201;137 :1-13.
Reinehr T. Inflammatory Markers in Children and Adolescent with Type 2 Diabetes Mellitus. Clinica Chimica Acta .2019;496:100–107
Karastergiu K, Smith SR, Greenberg As, & Fried SK. Sex Difference in Human Adipose Tissue- The Biology of Pear Shape. Biology of Sex Differences.2012;3:13.
Febriza A, Ridwan, As’ad S, Kasim VN, & Indrus HH. Adiponectin and It's Role in Inflammatory Process of Obesity. Mol Cell Biomed Sci. 2019; 3(2): 60-6.
Downloads
Additional Files
Published
How to Cite
Issue
Section
License
Copyright Notice
All articles submitted by the author and published in the Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan, are fully copyrighted by the publication of Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan under the Creative Commons Attribution-NonCommercial 4.0 International License by technically filling out the copyright transfer agreement and sending it to the publisher
Note :
The author can include in separate contractual arrangements for the non-exclusive distribution of rich versions of journal publications (for example: posting them to an institutional repository or publishing them in a book), with the acknowledgment of their initial publication in this journal.
Authors are permitted and encouraged to post their work online (for example: in an institutional repository or on their website) before and during the submission process because it can lead to productive exchanges, as well as earlier and more powerful citations of published works. (See Open Access Effects).
