The Correlation Between Adiponectin Levels With C-Reactive Protein in Adult Obese Non-Diabetic Among Staffs of DR. M. Djamil Hospital Padang

Dian Eka Putri, Rismawati Yaswir, Desywar Desywar, Efrida Efrida


The adiponectin and C-reactive protein (CRP) are markers of chronic low-grade inflammation related to obesity. This study aims to determine a correlation between adiponectin level and CRP level in adult obese individuals. This study was analyzed with a cross-sectional design of 55 subjects at Dr. M Jamil Central Hospital Padang from January to September 2019. The subjects included were type 1 obese (25≤BMI≤29.9 kg/m2) and type 2 obese (BMI 30.0 kg/m2). Enzyme-linked immunoassay (ELISA) was used to measure adiponectin and High Sensitivity C-Reactive Protein (Hs-CRP) levels. Univariate statistical analysis is processed and presented in distribution, frequency, mean (standard deviation), median (minimum-maximum value). Bivariate data were analyzed using the Pearson correlation test, significant if p<0.05. The study consists of 16 males and 39 females. The mean age was 35 years old (the range 23 to 57 years old), the mean BMI was 30.8 (4.5) kg/m2. This study consists of 28 subjects, type 1 obese and 27 types II obese. The mean adiponectin level in type 2 obese is lower than in type 2 obese groups. The mean CRP levels are high in all populations. Pearson ln-adiponectin and CRP correlation test in the entire population: r =-0.105 (p=0.444). 


Adiponectin, Chronic low grade inflammation, C-reactive protein, Obesity.

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Abraham PA, Attipoe S, Kazman JB, Zeno SA, Poth M, Deuster PA. Role Of Plasma Adiponectin / C-Reactive Protein Ratio In Obesity And Type 2 Diabetes Among African Americans. Afri Health Sci.2017;17(1):99-107.

Asghar A, Sheikh N. Role Of Immune Cells In Obesity Induced Low Grade Inflammation And Insulin Resistance. Cellular Immunology. 2017; 315:18–26.

Ellulu MS, Patimah I, Khaza'ai H, Rahmat A, Abed Y. Obesity And Inflammation: The Linking Mechanism And The Complications. Arch Med Sci. 2017;4:851–863.

Susantiningsih T, Mustofa S. Ekspresi IL-6 Dan TNF-α Pada Obesitas. JK Unila. 2018;2(2):1-7.

Jain V, Kumar A, Agarwala A, Vikram N, Ramakrishnan L. Adiponectin, Interleukin-6 And High-Sensitivity C-Reactive Protein Levels In Overweight/Obese Indian Children. Indian Pediatrics. 2017:(54), 858-861.

Regina F, Tirtamulia K, Warouw SM. Adiponectin And Highly Sensitive C-Reactive Protein, Levels In Obese Children Aged 9 To 15 Years. Paediatr Indones. 2011;51(1):7-11.

Li J, Liao C, Su H, Peng Q, Zhang Z, Yan S,Yang Q. The Relationship Among Adiponectin, High Sensitive C Reactive Protein And Triacylglycerol Level In Healthy Young Persons, Lipids In Health And Disease. 2011;10(109): 1-5.

Goksen D, Levent E, Kar S, Özen S, D S. Serum Adiponectin And hsCRP Levels And Non-Invasive Radiological Methods In The Early Diagnosis Of Cardiovascular System Complications In Children And Adolescents With Type 1 Diabetes Mellitus. J Clin Res Pediatr Endocrinol 2013;5(3):174-181

Al-Hamodi Z, AL-Habori M, Al-Meeri, Saif-Ali R. Association Of Adipokines, Leptin/Adiponectin Ratio And C-Reactive Protein With Obesity And Type 2 Diabetes Mellitus. Diabetol Metab Syndr 2014;6(99):1-8.

Balsan GA, Vieira JL, Oliveira AM, Portal VL. Relationship Between Adiponectin, Obesity And Insulin Resistance. Rev Assoc Med Brass. 2015;61(1):72–80.

Fang H, Judd RL. Adiponectin Regulation And Function. Comprehensive Physiology, 2018;8: 1031–1063.

Yu N, Ruan Y, Gao X, Sun J. Systematic Review And Meta-Analysis Of Randomized, Controlled Trials On The Effect Of Exercise On Serum Leptin And Adiponectin In Overweight And Obese Individuals. Horm Metab Res. 2017;49(03):164–173.

Kawamoto R, Kusunoki T, Abe M, Kohara K, & Miki T. An Association Between Body Mass Index And High-Sensitivity C-Reactive Protein Concentrations Is Influenced By Age In Community-Dwelling Persons. An International Journal Of Biochemistry And Laboratory Medicine. 2013: 50(5), 457–464.

Ahonen TM, Saltevo J. T., Kautiainen, H. J., Kumpusalo, E. A., & Vanhala, M. J. The Association Of Adiponectin And Low-Grade Inflammation With The Course Of Metabolic Syndrome. Nutrition, Metabolism And Cardiovascular Diseases. 2012. 22(3), 285–291. Doi:10.1016/J.Numecd.2010.07.001

Delongui F, Kallaur AP, Oliveira SR, Bonametti AM, Grion CMC, Morimoto HK, et al., Serum Levels Of High Sensitive C Reactive Protein In Healthy Adults From Southern Brazil. Journal Of Clinical Laboratory Analysis. 2013; 27(3):207–210.

Choi J, Joseph L, & Pilote L. Obesity And C-Reactive Protein In Various Populations: A Systematic Review And Meta-Analysis. Obesity Reviews, 2012:14(3):232–244.

Sproston NR, & Ashworth JJ. Role of C-Reactive Protein at Sites of Inflammation and Infection. Frontiers in Immunology. 2018;9(757):1-11.

Ding D, Wang M, Su D, Hong C, Li X, Yang Y, Zang Y, Hu G, Ling W. Body Mass Index, High Sensitity C-Reactive Protein And Mortality In Chinese With Coronary Artery Disease. Plose One. 2015;10(8):1-11.

Conroy SM, Chai W, Lim U, Franke AA, Cooney RV,& Maskarinec G. Leptin, Adiponectin, and Obesity among Caucasian and Asian Women. Mediators of Inflammation.2011; 1–7.

Amudi T, Pandelaki K, & Palar S. Hubungan antara hs-CRP , Adiponektin, Fetuin A terhadap Resistensi Insulin pada Pria Dewasa Muda dengan Obesitas Sentral. e-CliniC. 2021;9(1):231-237

Diagnostics Biochem Canada, Adiponectin Elisa, 2018a; Ref: CAN-APN-5000: 1-2.

Diagnostics Biochem Canada. High Sensitivity C-Reactive Protein (CRP) Elisa.2018b; Ref: CAN CRP-4360 :1-2.

Dahlan MS. Hipotesis Korelatif, Dalam Statistik Untuk Kedokteran Dan Kesehatan. Seri 1.Jakarta: Sagung Seto. 2014; 6: 223-24.

Engin, A. Adiponectin-Resistance in Obesity. Advances in Experimental Medicine and Biology. Springer International Publishing. 2017;18.415–441.

Pangestu YM, Sarah M, Warouw S, Tatura SN. Hubungan kadar 25-hydroksivitamin D dan high molecular weight adiponectin pada remaja obes. Sari Pediatri; 17(1):64-70.

El husseny MWA, Mamdouh M, Shaban S, Ibrahim Abushouk A, Zaki MMM, Ahmed OM, & Abdel-Daim MM. Adipokines: Potential Therapeutic Targets for Vascular Dysfunction in Type II Diabetes Mellitus and Obesity. Journal of Diabetes Research, 2017, 1–11.

Ebron K, Andersen C J, Aguilar D, Blesso C N, Barona J, Dugan CE, et al. A Larger Body Mass Index Is Associated With Increased Atherogenic Dyslipidemia, Insulin Resistance, And Low-Grade Inflammation In Individuals With Metabolic Syndrome. Metabolic Syndrome And Related Disorders. 2015;13(10):458–464.

Ahmed B, Sultana R, & Greene MW. Adipose Tissue and Insulin Resistance in Obese. Biomedicine & Pharmacotherapy. 20201;137 :1-13.

Reinehr T. Inflammatory Markers in Children and Adolescent with Type 2 Diabetes Mellitus. Clinica Chimica Acta .2019;496:100–107

Karastergiu K, Smith SR, Greenberg As, & Fried SK. Sex Difference in Human Adipose Tissue- The Biology of Pear Shape. Biology of Sex Differences.2012;3:13.

Febriza A, Ridwan, As’ad S, Kasim VN, & Indrus HH. Adiponectin and It's Role in Inflammatory Process of Obesity. Mol Cell Biomed Sci. 2019; 3(2): 60-6.


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