Analysis of Reticulocyte Hemoglobin Equivalent Levels in Patients with Chronic Kidney Disease Stage IV and V
DOI:
https://doi.org/10.33533/jpm.v15i1.2718Keywords:
RET-He, Iron Status, Anemia, CKDAbstract
Reticulocyte hemoglobin equivalent (RET-He) represents hemoglobin content in reticulocyte. Reticulocyte hemoglobin equivalent test can be used to asses iron status of chronic kidney disease (CKD). Iron deficiency happens in 40% CKD and could lead to anemia manifestation. Level of RET-He gives real-time assesment of iron availability for hemoglobin production and the level will getting lower when iron storage for erythropoiesis decreasing. Reticulocyte hemoglobin equivalent is more stabil than feritin and transferin saturation in assessing iron status. Aim of this study is to determine RET-He level in patients with CKD stage IV and V. This study is a cross sectional descripstive study. Subjects were 96 CKD stage IV and V patients that met inclusion and exclusion criterias. Subjects conducted blood tests at Central Laboratory Installation Dr. M. Djamil Hospital Padang from July to September 2020. Examination of RET-He level was analyzed by Sysmex XN-1000 flowcytometry fluorescense method. Data was presented in frequency distribution table. The RET-He level below cutoff (<29,2 pg) indicates the need for iron suplementation therapy for CKD stage IV and V patients. Samples with RET-He level below cutoff were 48 (50%) and 48 (50%) were above cutoff.References
National Collaborating Center for Chronic Conditions. Chronic Kidney disease: National Clinical Guideline For Early Identification and Management in Adults in Primary and Secondary Care. London : Royal College of Physicians. 2008; 21–4
Chasani S, Saktini F, Ramadhan M. Perbandingan Kualitas Hidup Pasien Penyakit Ginjal Kronik yang Diterapi dengan Continous Ambulatory Peritoneal Dialysis atau Hemodialisis.. Jurnal Kedokteran Diponegoro (JKD). 2017;6(4):1518–28.
Bilal A, Zaman FU, Abrar SM, Rahim S, Hussain MA, Shah SA. Effect of Age and Gender on Acute Copplications of Hemodialysis in Patients With Chronic Kidney Disease Secondary to Diabetes Mellitus.Pakistan Armed Forces Medical Journal. 2020;70(3):781–6.
Khan S, Ahmad I, Um-e-Kalsoom. Impact of Hemodialysis on The Wellbeing of Chronic Kidney Diseases Patients: a Pre-Post Analysis. Middle East Current Psychiatry. 2020; 27:54
Kementrian Kesehatan. Infodatin (Pusat Data dan Informasi Kementrian Kesehatan RI). 2017; ISSN: 2442-7659
Hill NR, Fatoba ST, Oke JL, Hirst JA, Callaghan AO, Lasserson DS, et al. Global Prevalence of Chronic Kidney Disease – A Systematic Review and Meta-Analysis. 2016;1–18.
Aisara S, Azmi S, Yanni M. Gambaran Klinis Penderita Penyakit Ginjal Kronik yang Menjalani Hemodialisis di RSUP Dr. M. Djamil Padang. Jurnal Kesehatan Andalas. 2018; 7(1): 42-50.
National Kidney Foundation (NKF) - KDOQI. KDOQI Clinical Practice Guidelines and Clinical Practice Recommendations for Anemia in Chronic Kidney Disease. Am J Kidney Dis. 2006; 47(5 Suppl 3): S11-145.
Official Journal Of The International Society Of Nephrology KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease. Diagnosis and Evaluation of Anemia in CKD. Kidney International Supplements. 2012; 2(4): 288-91
Wirawan R, Tedja AT, Henrika F, Lydia A. Concordance between Reticulocyte Hemoglobin Equivalent and Reticulocyte Hemoglobin Content in CKD Patients Undergoing Hemodialysis. 2000;49(1):34–40.
Hayes W. Measurement of iron status in chronic kidney disease. 2019;605–13.
Geddes CC. Pathophysiology of renal anaemia. 2018;(August):1–2.
Means R.T. dan B. Glader. Anemia: General Considerations. Dalam Wintrobe’s Clinical Hematology 13rd. Philadelphia :Wolters Kluwer. 2014; 587-616
Fishbane S, Spinowitz B. Update on Anemia in ESRD and Earlier Stages of CKD : Core Curriculum 2018. Am J Kidney Dis [Internet]. 2018;71(3):423–35. Available from: https://doi.org/10.1053/j.ajkd.2017.09.026
Xhulia D, Gerta J, Dajana Z, Koutelekos I, Vasilopoulou C. Needs of Hemodialysis Patients and Factors Affecting Them. Global J Health Sci. 2016;8(6):109–20.
Suwitra K. Penyakit Ginjal Kronik. Dalam: Setiati S, Alwi I, Sudoyo A, Simadibrata M, Setyohadi B, Syam AF, editor (penyunting). Buku ajar ilmu penyakit dalam. Edisi Ke-6. Jakarta Pusat: Interna Publishing; 2014; hlm. 2159
Mikhail A, Brown C, Williams JA, Mathrani V, Shrivastava R, Evans J, et al. Renal association clinical practice guideline on Anaemia of Chronic Kidney Disease. 2017;1–29.
Wyck DB Van, Jr HA, Gupta R. Analytical and Biological Variation in Measures of Anemia and Iron Status in Patients Treated With Maintenance Hemodialysis. YAJKD [Internet]. 2010;56(3):540–6. Available from: http://dx.doi.org/10.1053/j.ajkd.2010.05.009
Sysmex Educational Enhancement and Development. The importance of reticulocyte detection. 2016; 1-8.
Atkinson MA, Warady BA. Anemia in Chronic Kidney Disease. Pediatr Nephrol. 2017; 33:227–38.
Downloads
Additional Files
Published
How to Cite
Issue
Section
License
Copyright Notice
All articles submitted by the author and published in the Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan, are fully copyrighted by the publication of Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan under the Creative Commons Attribution-NonCommercial 4.0 International License by technically filling out the copyright transfer agreement and sending it to the publisher
Note :
The author can include in separate contractual arrangements for the non-exclusive distribution of rich versions of journal publications (for example: posting them to an institutional repository or publishing them in a book), with the acknowledgment of their initial publication in this journal.
Authors are permitted and encouraged to post their work online (for example: in an institutional repository or on their website) before and during the submission process because it can lead to productive exchanges, as well as earlier and more powerful citations of published works. (See Open Access Effects).
