Analyzing Parental Age to Determine Types of Cleft in Hayandra Peduli Foundation Patient, Indonesia

Karina Karina, Fransisca Fransisca, Kevin Leonard Suryadinata


Cleft lip and palate are complex and known to have multifactorial risk factors with a prevalence of 0.2% in Indonesia. Also, there is no specific data about parental age-related to types of a cleft in Indonesia. This study aims to analyze parental age-related to types of cleft in patients treated by Hayandra Peduli Foundation, Indonesia. The data was collected from 2014 to 2018 from social service held by Hayandra Peduli Foundation. The data collected primarily, and 604 subjects were obtained. The results showed that 81.5% of patients were 0-5 of age, with patients' distribution were 356 male patients and 248 female patients. There was no significant correlation between maternal age and each type of cleft. Furthermore, there was no correlation between paternal age and types of cleft based on maternal group age. For young and ideal maternal group age, their p-value showed no significant correlation (p-value 0.393 for young maternal age and 0.941 for ideal maternal age). Surprisingly, the old maternal group age shows significant results, with a p-value of 0.045. In conclusion, we found that cleft palate will occur in infants born from an aging mother (>35 years old).


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[1] Wahyuni N, Latifah S. Kondisi Lingkungan di Nusa Tenggara Timur dan Prevalensi Kejadian Celah Bibir dan Celah Langitan. BIMKMI. 2016;4(1):7.

[2] Natsume N, Tolarova MM. Epidemiology of Cleft Lip and Palate. Tokyo: Quintessence Publishing Co., Ltd, 2006.

[3] Rychtarikova J, Gourbin C, Sipek A, Wunsch G. Impact of parental ages and other characteristics at childbearing on congenital anomalies: Results for the Czech Republic, 2000-2007. Demograph. Res. 2013;28:137-176.

[4] DeRoo LA, Gaudino JA, Edmonds LD. Orofacial cleft malformations: associations with maternal and infant characteristics in Washington State. Birth Defects Res A Clin Mol Teratol. 2003; 67(9):637-42.

[5] Martelli DRB, Cruz KW, Barros LM, Silveira MF, Swerts MSO, Junior HM. Maternal and Paternal Age, Birth Order, and Interpregnancy Interval Evaluation for Cleft Lip-Palate. Braz J Otorhinolaryngol. 2010;76(1):107-12.

[6] Salihu S, Krasniqi B, Sejfija O, Heta N, Salihaj N, Geci A, et al. Analysis of Potential Oral Cleft Risk Factors in the Kosovo Population. Int Surg. 2014;99:161-5.

[7] Luo YL, Cheng YL, Gao XH, Tan QS, Li JM, Wang W, et al. Maternal Age, Parity and Isolated Birth Defects: A Population-Based Case-Control Study in Shenzhen, China. Plos one. 2013;8:1-6.

[8] Bille C, Skytthe A, Vach W, Knudsen LB, Andersen AMN, Murray JC, et al. Parent's Age and the Risk of Oral Clefts. Epidemiol. 2005;16(3):311-316.

[9] Berg E, Lie RT, Sivertsen A, Haaland. Parental Age and the Risk of Isolated Cleft Lip : A Registry-Based Study. Annals of Epidemiol. 2015;xxx:1-6.

[10] Herkrath AP1, Herkrath FJ, Rebelo MA, Vettore MV. Parental age as a risk factor for nonsyndromic oral clefts: a meta-analysis. J Dent. 2012;40(1):3-14.

[11] Harville EW1, Wilcox AJ, Lie RT, Abyholm F, Vindenes H. Epidemiology of cleft palate alone and cleft palate with accompanying defects. Eur J Epidemiol. 2007;22(6):389-395.

[12] Hermann NV, Darvann TA, Munch A, Kreiborg S. Parental age in relation to the severity of cleft lip and/or palate. Orthod Craniofac Res. 2018;21(4):236-241.

[13] Vieira AR, Orioli IM, Murray JC. Maternal age and oral clefts: a reappraisal. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002;94:530–535.

[14] Balgir RS. Parental age and incidence of cleft lip and cleft palate anomalies. Acta Anthropogenet. 1984;8(3-4): 231-5.

[15] Penrose LS. Parental age and mutation. Lancet. 1995;269:312-3.

[16] Keightley PD. Rates and fitness consequences of new mutation in human. Genetics. 2012;190:295-304.


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