ICAM-1 and S100β plasma value in children with sepsis

Lisa Safira; Anton H Pudjiadi; Sukman Tulus Putra

doi:10.33533/jpm.v14i1.1645

Authors

Lisa Safira Fakultas Kedokteran, UPN Veteran Jakarta
Anton H Pudjiadi Fakultas Kedokteran, Universitas Indonesia
Sukman Tulus Putra Fakultas Kedokteran, Universitas Indonesia

DOI:

https://doi.org/10.33533/jpm.v14i1.1645

Keywords:

Sepsis, ICAM-1, S100β

Abstract

ICAM-1 release during sepsis is perceived to be related to brain injury. Whereas S100β has been known as one of brain injury markers.To measure mean value of ICAM-1, S100β, to find correlation between ICAM-1 and Glasgow Coma Scale (GCS), between S100β and GCS, also ICAM-1 and S100β.Analytical cross sectional study in 34 sepsis children, measurement of ICAM-1 and S100β plasma levels within day 1 and 3 since diagnosis of sepsis.Median level of ICAM-1 day one 548,1 (158,6 – 1256,1) ng/mL and day three 596,5 (185,5 – 1264,5) ng/mL (p=0,164). S100β median is significantly higher in severe than mild sepsis (p=0,008 dan p=0,021). On third day S100β was negatively related to GCS (r= - 0,452; p=0,003). The correlation observed between ICAM-1 and S100β on day one was r=0,146 (p=0,409) while on third day was r=0,184 (p=0,298).The prevalence of encephalopathy sepsis is 5.9%, Median ICAM-1 is higher on day three. Median of S100β is higher in severe than mild sepsis.There is no correlation between ICAM-1 and GCS in both sepsis. There was negative correlation between S100β and GCS on 3rd day of sepsis. No correlation between ICAM-1 and S100β on both measurement days.

References

[1] Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med. 2003;348:1546-54.

[2] Watson RS, Carcillo JA, Zwirble WT, Clermont G, Lidicker J, Angus DC. The epidemiology of severe sepsis in children in the United States. Am J Respir Crit Care Med. 2003;167:695-701.

[3] Bagian Rekam Medis RSCM. Data pasien rawat inap Departemen Ilmu Kesehatan Anak 2009 - 2012. 2013.

[4] Stanimirovic D, Satoh K. Inflammatory mediators of cerebral endothelium: a role in ischemic brain inflammation. Brain Pathol. 2000;10:113-26.

[5] Kim MJ, Kim T, Suh GJ, Kwon WY, Kim KS, et.al. Association between the simultaneous decrease in the levels of soluble vascular cell adhesion molecule-1 and S100 protein and good neurological outcomes in cardiac arrestsurvivors. Clin Exp Emerg Med 2018;5(4):211-218.

[6] Stocchetti N. Brain and sepsis: functional impairment, structural damage, and markers. Anesth Analg. 2005;101:1465-9.

[7] Apostolou M, Dimitriou H, Kaleyias J, Perdikogianni C, Stiakaki E, Costalos C dkk. Levels of soluble ICAM-1 in premature and full-term neonates with infection. Mediators Inflamm. 2002;11:95-8.

[8] Hsu AA, Fenton K, Weinstein S, Carpenter J, Dalton H, Bell MJ. Neurological injury markers in children

[9] Routsi C, Stamataki E, Nanas S, Psachoulia C, Stathopoulos A, Koroneos A dkk. Increased levels of serum S100B protein in critically ill patients without brain injury. SHOCK. 2006;26:20-4.

[10] Sharshar T, Hopkinson NS, Orlikowski D, Annane D. Science review: the brain in sepsis - culprit and victim. Crit Care. 2004;9:37-44.

[11] Luce WA. Bench to bedside review: developmental influences on the mechanisms, treatment and outcomes of cardiovascular dysfunction in neonatus vs adult sepsis. Crit Care. 2007;11:1-9.

[12] Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001;29:1303-10.

[13] Huh JW, Raghupathi R. New concepts in treatment of pediatric traumatic brain injury. Anesthesiol Clin. 2009;27:213-40.

[14] Bustamante GPS, Licona NA, Sabanero GB, Mendoza JMG, Briones SL, Águas CIM dkk. Intercellular adhesion molecules and mortality for sepsis in infants younger than 1 year of life. Rev Invest Clin. 2011;63:601-6.

[15] McKeating EG, Andrews PJD, Mascia L. Leukocyte adhesion molecule profiles and outcome after traumaic brain injury. Acta Neurochir Suppl. 1998;71:200-2.

[16] Nguyen DN, Spapen H, Su F, Schiettecatte J, Shi L, Hachimi-Idrissi. Elevated serum levels of S100b protein and NSE are associated with brain injury in patients with severe sepsis and septic shock. Crit Care Med. 2006;34:1967-74.

[17] Towned W, Dibble C, Abid K, Vail A, Sherwood R, Lecky F. Rapid elimination of protein S-100B from seum after minor head trauma. J Neurotrauma. 2006;23:149-55.

[18] Jackson RG, Samra GS, Radcliffe J, Clarck GH, Price CP. The early fall in levels of S-100B in traumatic brain injury. Clin Chem Lab Med. 2005;38:1165-7.

[19] Piazza O, Russo E, Cotena S, Esposito G, Tufano R. Elevated S100B levels do not correlate with the severity of encephalopathy during sepsis. Brith J Anaesth. 2007;99:521.

[20] El-Deen AE, Hammad S, El-Bendary A. Preoperative serum S100B protein as a prognostic marker for traumatic brain injury patients. E J N S. 2009;24:135-52.

[21] Tsao N, Hsu HP, Wu CM, Liu CC, Lei HY. TNF-a causes an increase in blood-brain barrier permeability during sepsis. J Med Microbiol. 2001;50:812-21.