Overtraining of aerobic physical exercise reduce rats (Rattus norvegicus) memory

Ni Made Ridla Parwata

doi:10.33533/jpm.v14i1.1591

Authors

Ni Made Ridla Parwata Politeknik Kesehatan Kemenkes Palu

DOI:

https://doi.org/10.33533/jpm.v14i1.1591

Keywords:

Overtraining, Memory, Hippocampus

Abstract

Overtraining syndrome is a decrease in physical capacity, emotions and immunity due to training that is too often without adequate periods of rest. Overtraining is often experienced by athletes who daily undergo heavy training with short break periods. This research aims to look at the effect of overtraining aerobic physical exercise on memory in mice. The research method was experimental in vivo with the subject of adult male rat (Rattus Norvegicus) Winstar strain aged 8-10 weeks, body weight 200-250 gr. Divided into three groups, namely the control group, aerobic group and overtraining group. The results of memory tests with water E Maze showed an increase in the duration of travel time and the number of animal errors made by the overtraining group (p = 0.003). This study concludes that overtraining aerobic physical exercise can reduce memory in rat hippocampus.

Author Biography

Ni Made Ridla Parwata, Politeknik Kesehatan Kemenkes Palu

Depertemen : Politeknik Kesehatan Kemenkes Palu, Jurusan Keperawatan Prodi D III Keperawatan Poso

Pangkat : Penata Muda Tkt I, III/b

Jabatan : Asisten Ahli

References

[1] Tong L, Shen H, Perreau VM, Balazs R, Cotman CV. Effects Exercise On Gene Expression Profil In The Rat Hipocampus. Neurobiol. 2001; Dis.8(6):1046-56.

[2] Neeper, S.A, Gomez PF, Choi J, Cotman CW. Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain. Brain Res. 1996; 726, 49–56.

[3] Diamond,MC. Response Of The Brain To Enrichment. Anais de academia brasileira de ciencas. 2001; 73(2):211-20.

[4] Nuno FM, Richard JW, and Craig AW. Prevalence of Nonfunctional Overreaching/ Overtraining in Young English Athletes. Medical Scientic Sports Exercise. 2011; 43, 287–94.

[5] Morgan WP, O’Connor PJ, Sparling PB, et al. Psychologic Characterization Of The Female Elite Distance Runner.Int J Sports Med. 1987; 8:124-31.

[6] Dong HK, Bum SK, Hyukki C, Young IK, SangmeeAJ,Yea HL. Ameliorates Exercise cognition impairment due to restraint stress-induced oxidative insult and reduced BDNF level. Biochemical and biophysical Reseach communication. 2013; 434: 245-51.

[7] Boulanger L, Poo MM. Presynaptic Depolarization Facilitates Neurotrophin Induced Synaptic Potentiation. Nat Neuroscience. 1999; 2:346-51.

[8] Surjono TW. Pengaruh pendedahan Pralahir Rubratoksin B Terhadap Perkembangan Pralahir dan Perilaku Pasca lahir Serta Penampilan Reproduksi Turunan F1 Mencit (Mus musculus) Swiss Webster [Disertasi]. Bandung: ITB; 1997.

[9] Carlson NR. Physiology of Behavior. 11th Edition. USA: Pearson Education, Inc; 2013.

[10] Diamond,MC. Response Of The Brain To Enrichment. Anais de academia brasileira de ciencas. 2001; 73(2):211-20.

[11] Kobilo T, Henriette VP.Muscle Fatiq And Cognition: What Is The Link?.2011. Learning And Memory. 18, 103–07.

[12] Borght KVD, Havekes R, Bos T, Eggen BJL,Van DZ. Exercise Improves Memory Acquisition and Retrieval in The Y Maze Task: Relationship With Hippocampal Neurogenesis. Bahav Neurosci. 2007;121(2):324-34.

[13] Mizuno M, Yamada K, Jue He, et al. Involvement of BDNF Receptor TrkB in Spatial Memory Formation. Learning and Memory. 2003; 10: 108-15.

[14] Yu FL, Hsiun IC, Chao LW, et al. Differential effects of treadmill running and wheel running on spatial or aversive learning and memory: roles of amygdalar brain-derived neurotrophic factor and synaptotagmin I. Journal Physiology 2009. 587.13; 3221–31.

[15] Helga O, Istvan B, Shuzo K, Takao K, Shoichi T, Sataro G, et al. The effects of moderate-, strenuous- and over-training on oxidative stress markers, DNA repair, and memory, in rat brain. Neurochemistry International. 2005; 46: 635–40.

[16] Eloi FR, Takahashi S, Aboulafia J, et al. Oxidative Stress Induched By Intensive And Exhaustive Exercise Impair Murine Cognition Fungtion. J Neurophysiology. 2007; 98:1820-26.

[17] John A K, Diana S, Woodruff P. A comparison of low- and high-impact forced exercise: Effects of training paradigm on learning and memory. Physiology and Behavior. 2012; 106:423 – 27.

[18] Fry RW, Morton, AR, Keast D. Overtraining in athletes: an update. Sports Med. 1991; (12):32–65.