FORMULATION OF EMULGEL CONTAINING ROBUSTA GREEN COFFEE (COFFEA CANAPHORA) EXTRACT

Keywords

Robusta green coffea extract, emulgel, chlorogenic acid

How to Cite

Evma Rahayu, F., & Kusnawardhani, I. F. (2024). FORMULATION OF EMULGEL CONTAINING ROBUSTA GREEN COFFEE (COFFEA CANAPHORA) EXTRACT: FORMULATION OF EMULGEL CONTAINING ROBUSTA GREEN COFFEE (COFFEA CANAPHORA) EXTRACT. Journal of Research in Pharmacy and Pharmaceutical Sciences, 3(1), 26–33. https://doi.org/10.33533/jrpps.v3i1.7770

Abstract

Robusta green coffee (Coffea canephora) contains chlorogenic acid compounds, caffeine, carbohydrates, fats, amino acids, volatile compounds, and minerals. Robusta green coffee extract is formulated in the form of emulgel as a topical application because of the potential for chlorogenic acid to improve dry skin diseases. The purpose of this study was to formulate an extract of robusta green coffee (Coffea canephora) in the form of an emulgel and to determine the physical characteristics and stability of the emulgel. The research design used is the experimental method. This research begins with the extraction of robusta green coffee using the maceration method, phytochemical screening, and the manufacture of emulgel preparations with variations in the ratio of emulsion and gel, namely F0 (1:6), F1 (1:6), F2 (3:6), and F3 (6:6). The process of making emulgel is making emulsion, making gel, and incorporating emulsion into gel. The evaluation carried out on the emulgel preparation included physical examination, determination of pH, emulsion type test, viscosity test, centrifugation test, and freeze and thaw test. The results of the physical characteristics of the emulgel preparation were good and met the requirements based on the parameters of physical examination, determination of pH, and emulsion type test and stable emulgel preparation in freeze thaw stability testing based on parameters of physical examination, determination of pH, emulsion type test, and centrifugation test. Analysis of chlorogenic acid levels in emulgel preparations using UV-Vis spectrophotometer. The levels of chlorogenic acid in the emulgel preparations did not contain chlorogenic acid (F0), 76.70% (F1), 82.77% (F2), and 79.64% (F3).

https://doi.org/10.33533/jrpps.v3i1.7770

References

Auliasari, N., Gozali, D., & Santiani, A. 2016. Formulasi Emulgel Ekstrak Daun Jambu Air (Syzygium aqueum (Burm.f.) Alston) Sebagai Antioksidan. Jurnal Farmako Bahari. 7(2), 1-11.

Daud, N. S. & Suyanti, E. 2017. Formulasi Emulgel Antijerawat Minyak Nilam Menggunakan Tween 80 dan Span 80 Sebagai Pengemulsi Dan HPMC Sebagai Basis Gel. Jurnal Mandala Pharmacon Indonesia. 3(2), 90-95.

Direktorat Jendral Perkebunan. 2020. Produksi Kopi Menurut Provinsi di Indonesia, 2015-2019. 1 hlm

Erwiyani, A. R., Ayu, S. M., Ningtyas, W. A., & Vifta, R. L. 2022. Formulasi Dan Evaluasi Sediaan Emulgel Daging Buah Labu Kuning (Cucurbita maxima L.). Jurnal Ilmiah Farmasi. 68-78.

Farhaty, N. & Muctharidi. 2016. Tinjauan Kimia Dan Aspek Farmakologi Senyawa Asam Klorogenat Pada Biji Kopi: Review. Farmaka Suplemen. 14(1), 214-227.

Husniati, H., Sari, M. Y., & Sari, A. 2021. Kajian: Karakterisasi Sennyawa Aktif Asam Klorogenat Dalam Kopi Robusta Sebagai Atioksidan. Majalah Teknologi Agro Industri. 12(2), 34-39.

Istiqomah, N, Akuba, J., & Taupik, M. 2021. Formulasi Emulgel Dari Ekstrak Daun Kelor (Moringa oleifera LAM) Serta Evaluasi Aktivitas Antioksidan Dengan Metode DPPH. Journal Syifa Sciences and Clinical Research. 3(1), 9-18.

Mendhekar, S. Y., Jori, R. R., Shinde, K. R, Jadhav., & Gaikwad. 2017. Formulationand Evaluastion of Polyherbal Vanishing Plus Fairness Expert Cream. Journal of Pharmacy and Pharmaceutical Science. 6(12), 1268-1277.

Pangestu, A. R. 2020. Perbandingan Kecepatan Proses Penyembuhan Luka Swiss Webster Dengan Kopi Robusta Dan Arabika. Jurnal Ilmiah Kesehatan Sandi Husada. 9(2), 812-816.

Priani, S. E., Permana, R. A., Nurseha, M., & Aryani, R. 2021. Pengembangan Sediaan Emulgel Antioksidan Dan Tabir Surya Mengandung Ekstrak Kulit Buah Cokelat (Theobroma cacao L). Jurnal Farmasi Dan Ilmu Kefarmasiaan Indonesia. 8(3), 264-270.

Purwanti, W. 2021. Pengaruh Formulasi Kopi Hijau Dan Kopi Sangrai Terhadap Sifat Kimia, Mikrobiologi Dan Nilai Kadar Sari Kopi Cold Brew Dengan Variasi Lama Penyeduhan. Fakultas Pertanian Universitas Sriwijaya. Skripsi.

Puspitasari, D. F & Sofandi, A. 2020. Skrining Fitokimia, Formulasi Dan Uji Karakteristik Fisik Sediaan Double Emulsion Buah Kupa Kering (Syzgium Polycephalum Merr). Akfarindo. 5(1), 8-14.

Rahayu, F. E., Salman., & Lucida, H. 2020. Formulation And Characterization of Emulgel Containing Tomato’s Lycopene (Solanum Lycopersicum L.). World Journal of Pharmacy And Pharmaceutical Science. 9(12), 1072-1088.

Ratnapuri, P. H., Haitami, F., & Fitriana, M. 2019. Stabilitas Fisik Sediaan Emulgel Ekstrak Etanol Daging Buah Limpasu (Baccaurea lanceolate (Miq.) Mull. Arg.). Jurnal Pharmascience. 6(2), 8-18.

Rustiani, E., Andini, S., & Apriani, M. 2021. Formulasi Sediaan Emulgel Ekstrak Etanol 70% Daun Talas (Colocasia esculenta (L.) Schott) Dengan Variasi Konsentrasi Karbopol 940. Jurnal Farmasi. 2(1).

Sari, M. Y., Suhartati, T., & Husniati. 2019. Analisis Senyawa Asam Klorogenat Dalam Biji Kopi Robusta (Coffea canephora) Menggunakan HPLC. Analit : Analytical and Enviromental Chemistry. 4(2), 86-93.

Sohail, M., Naveed, A., Abdul, R., Gulfifishan, Khan, H. M. J., & Khan, H. 2018. An Approach to Enchanced Stability: Formulation and Characterization of Solanum Lycopersicum Derived Lycopene Based Topical Emulgel. Saudi Pharmaceutical Journal. 26, 1170-1177.

Sri, T & Rubiyanti, R. 2020. Pengaruh Pemberiaan Ekstrak Biji Kopi Arabika (Coffea arabica L.) Terhadap Histopatologi Lambung Tikus Putih Galur Wistar. Fitofarmaka Jurnal Ilmu Farmasi. 10(1), 32-41.

Suhartati, T. 2017. Dasar - Dasar Spektrofotometri UV-Vis Dan Spektrofotometri Massa Untuk Penentuan Struktur Senyawa Organik. Bandar Lampung: CV. Anugrah Utama Raharja.

Yadav, S. K., Mishra, M. K., Tiwaru, A., & Shukla, A. 2017. Emulgel: A New Approach for Enhanced Topical Drug Delivery. International Journal of Current Pharmaceutical Research. 9(1), 15-19.

All articles submitted by the author and published in the Journal of Research in Pharmacy and Pharmaceutical Sciences, are fully copyrighted by the publication of JJournal of Research in Pharmacy and Pharmaceutical Sciences under the Creative Commons Attribution-NonCommercial 4.0 International License by technically filling out the copyright transfer agreement and sending it to the publisher

Note :

The author can include in separate contractual arrangements for the non-exclusive distribution of rich versions of journal publications (for example: posting them to an institutional repository or publishing them in a book), with the acknowledgment of their initial publication in this journal.

Authors are permitted and encouraged to post their work online (for example: in an institutional repository or on their website) before and during the submission process because it can lead to productive exchanges, as well as earlier and more powerful citations of published works. (See Open Access Effects).