Hormonal and Laboratory Profile of Polycystic Ovarian Syndrome (Pcos) Women Visiting Fertility Center in Indonesia
DOI:
https://doi.org/10.33533/jpm.v18i1.7546Keywords:
Hormonal profile, Laboratory profile, Polycystic ovary syndromeAbstract
Our study aims to scrutinize the hormonal and laboratory profile of women with PCOS visiting a fertility center in Indonesia. A computerized database of 120 PCOS women and 120 controls was retrospectively reviewed and analyzed. According to analysis, the concentration of AMH and basal LH were significantly more elevated in the PCOS group than in the control group (6.77 vs. 2.05, P<0.001; and 6.8 vs. 5.3, P<0.001, respectively). The level of basal FSH was significantly lower in the PCOS group (5.83 vs. 7.86; P<0.001). After an IVF cycle, PCOS women had significantly higher retrieved oocytes and mature oocytes compared to controls (18 vs. 8, P<0.001; 12 vs. 6, P<0.001). The number of fertilizations, cleavages, and top-quality cleavages were also higher in the PCOS group than in the control group (10 vs. 4, P<0.001; 10 vs. 4, P<0.001; 4 vs. 2, P<0.001). At the blastocyst stage, patients with PCOS had a higher number of blastocysts and top-quality blastocysts than control (9 vs. 4, P<0.001); 4 vs. 1, P<0.01). However, the clinical pregnancy was significantly higher in the control group than in the PCOS group (52.6% vs. 16.7%; P = 0.045).
References
Jabeen A, Yamini V, Amberina AR, Eshwar MD, Vadakedath S, Begum GS, et al. Polycystic Ovarian Syndrome: Prevalence, Predisposing Factors, and Awareness Among Adolescent and Young Girls of South India. Cureus. 2022 Aug 13 [cited 2023 Jul 5];14(8). DOI: https://doi.org/10.7759/cureus.27943
2. Muharam R, Purba JS, Hestiantoro A, Elvira SD. Profile on personality types and cortisol in polycystic ovarian syndrome. Middle East Fertil Soc J. 2018 Sep 1;23(3):189–94. DOI: https://doi.org/10.1016/j.mefs.2017.12.001
Escobar-Morreale HF. Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nat Rev Endocrinol. 2018 May 1 [cited 2023 May 5];14(5):270–84. DOI: https://doi.org/10.1038/nrendo.2018.24
Franks S, Berga SL. Does PCOS have developmental origins? Fertil Steril. 2012;97:2–6. DOI: https://doi.org/10.1016/j.fertnstert.2011.11.029
Liao B, Qiao J, Pang Y. Central Regulation of PCOS: Abnormal Neuronal-Reproductive-Metabolic Circuits in PCOS Pathophysiology. Front Endocrinol (Lausanne). 2021 May 28;12:667422. DOI: https://doi.org/10.3389/fendo.2021.667422
Atoum MF, Alajlouni MM, Alzoughool F. A Case-Control Study of the Luteinizing Hormone Level in Luteinizing Hormone Receptor Gene (rs2293275) Polymorphism in Polycystic Ovarian Syndrome Females. Public Health Genomics. 2022 May 29 [cited 2024 Feb 12];25(3):89–97. DOI: https://doi.org/10.1159/000521971
Roca FJ, Schutt AK, Mazur EC, Gibbons WE, Kovanci E. Women with polycystic ovary syndrome experience more rapid decline in anti-mullerian hormone levels. Fertil Steril. 2012 Sep 1 [cited 2024 Feb 12];98(3):S116. DOI: https://doi.org/10.1016/j.fertnstert.2012.07.429
Butt MS, Saleem J, Aiman S, Zakar R, Sadique I, Fischer F. Serum anti-Müllerian hormone as a predictor of polycystic ovarian syndrome among women of reproductive age. BMC Womens Health. 2022 Dec 1 [cited 2024 Feb 12];22(1). DOI: https://doi.org/10.1186/s12905-022-01782-2
Szeliga A, Rudnicka E, Maciejewska-Jeske M, Kucharski M, Kostrzak A, Hajbos M, et al. Neuroendocrine Determinants of Polycystic Ovary Syndrome. Int J Environ Res Public Health. 2022 Mar 1 [cited 2024 Feb 15];19(5). DOI: https://doi.org/10.3390/ijerph19053089
Wolf WM, Wattick RA, Kinkade ON, Olfert MD. Geographical Prevalence of Polycystic Ovary Syndrome as Determined by Region and Race/Ethnicity. Int J Environ Res Public Health. 2018 Nov 20 [cited 2024 Feb 12];15(11). DOI: https://doi.org/10.3390/ijerph15112589
Tang K, Wu L, Luo Y, Gong B. In vitro fertilization outcomes in women with polycystic ovary syndrome: A meta-analysis. Eur J Obstet Gynecol Reprod Biol. 2021 Apr 1 [cited 2024 Mar 12];259:146–52. DOI: https://doi.org/10.1016/j.ejogrb.2021.02.023
Fauser BCJM, Tarlatzis, Fauser, Chang, Aziz, Legro, et al. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004 Jan [cited 2023 Jun 9];19(1):41–7. DOI: https://doi.org/10.1093/humrep/deh098
Rajbanshi I, Sharma VK, Tuladhar ET, Bhattarai A, Raut M, Dubey RK, et al. Metabolic and biochemical profile in women with polycystic ovarian syndrome attending tertiary care centre of central NEPAL. BMC Womens Health. 2023 Dec 1 [cited 2024 Feb 9];23(1):1–7. DOI: https://doi.org/10.1186/s12905-023-02379-z
Handayani N, Sundari AM, Aprilliana T, Boediono A, Polim AA, Sirait B, et al. Clinical Pregnancy Is Not Associated with Sperm Quality in POSEIDON Group 1 and 2 Patients. Andrologia. 2023 May 5;2023:1–8. DOI: https://doi.org/10.1155/2023/4637822
Gardner DK, Lane M, Stevens J, Schlenker T, Schoolcraft WB. Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer. Fertil Steril. 2000 Jun [cited 2022 Apr 8];73(6):1155–8. DOI: https://doi.org/10.1016/S0015-0282(00)00518-5
Lee TT, Rausch ME. Polycystic ovarian syndrome: role of imaging in diagnosis. Radiographics. 2012 Oct [cited 2023 Jul 10];32(6):1643–57. DOI: https://doi.org/10.1148/rg.326125503
Wiweko B, Maidarti M, Priangga MD, Shafira N, Fernando D, Sumapraja K, et al. Anti-mullerian hormone as a diagnostic and prognostic tool for PCOS patients. J Assist Reprod Genet. 2014;31(10):1311–6. DOI: https://doi.org/10.1007/s10815-014-0300-6
Sharma S, Majumdar A. Prevalence of metabolic syndrome in relation to body mass index and polycystic ovarian syndrome in Indian women. J Hum Reprod Sci. 2015 Oct 1 [cited 2024 Feb 13];8(4):202. DOI: https://doi.org/10.4103/0974-1208.170394
Toosy S, Sodi R, Pappachan JM. Lean polycystic ovary syndrome (PCOS): an evidence-based practical approach. J Diabetes Metab Disord. 2018 Dec 31 [cited 2024 Feb 13];17(2):277. DOI: https://doi.org/10.1007/s40200-018-0371-5
Chen X, Ni R, Mo Y, Li L, Yang D. Appropriate BMI levels for PCOS patients in Southern China. Hum Reprod. 2010 May 1 [cited 2024 Feb 13];25(5):1295–302. DOI: https://doi.org/10.1093/humrep/deq028
Yue C-Y, Lu L-K-Y, Li M, Zhang Q-L, Ying C-M. Threshold value of anti-Mullerian hormone for the diagnosis of polycystic ovary syndrome in Chinese women. 2018 [cited 2024 Feb 15]; DOI : https://doi.org/10.1371/journal.pone.0203129
Hassani F, Oryan S, Eftekhari-Yazdi P, Bazrgar M, Moini A, Nasiri N, et al. Association between The Number of Retrieved Mature Oocytesand Insulin Resistance or Sensitivity in Infertile WomenPolycystic Ovary Syndrome. Int J Fertil Steril. 2019 [cited 2024 Feb 15];12(4):310. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186286/
Plachot M, Belaisch-Allart J, Mayenga JM, Chouraqui A, Tesquier A, Serkine AM, et al. Qualité des ovocytes et embryons dans le syndrome des ovaires polykystiques. Gynecol Obstet Fertil. 2003 Apr 1 [cited 2024 Feb 15];31(4):350–4. DOI : https://doi.org/10.1016/S1297-9589(03)00059-6
Ciepiela P, Baczkowski T, Brelik P, Antonowicz A, Safranow K, Kurzawa R. Biotechnological and clinical outcome of in vitro fertilization in non-obese patients with polycystic ovarian syndrome. In: Folia Histochemica et Cytobiologica. 2007 [cited 2024 Feb 15]. p. 65–71. Available from: https://pubmed.ncbi.nlm.nih.gov/18292838/
Liu S, Mo M, Xiao S, Li L, Hu X, Hong L, et al. Pregnancy Outcomes of Women With Polycystic Ovary Syndrome for the First In Vitro Fertilization Treatment: A Retrospective Cohort Study With 7678 Patients. Front Endocrinol (Lausanne). 2020 Sep 25 [cited 2024 Feb 15];11:575337. DOI: https://doi.org/10.3389/fendo.2020.575337
Wiser A, Shehata F, Holzer H, Hyman JH, Shalom-Paz E, Son WY, et al. Effect of high LH/FSH ratio on women with polycystic ovary syndrome undergoing in vitro maturation treatment. J Reprod Med. 2013 May 1 [cited 2024 Feb 15];58(5–6):219–23. Available from: https://europepmc.org/article/med/23763006
Chung JO, Cho DH, Chung DJ, Chung MY. Associations among Body Mass Index, Insulin Resistance, and Pancreatic β-Cell Function in Korean Patients with New-Onset Type 2 Diabetes. Korean J Intern Med. 2012 Mar [cited 2024 Feb 15];27(1):66. DOI: https://doi.org/10.3904/kjim.2012.27.1.66
Tam Le M, Van Nguyen T, Thanh Nguyen T, Thanh Thi Nguyen T, An Thi Nguyen T, Huy Vu Nguyen Q, et al. Does polycystic ovary syndrome affect morphokinetics or abnormalities in early embryonic development? Eur J Obstet Gynecol Reprod Biol X. 2019 Jul 1 [cited 2024 Feb 16];3:100045.DOI: https://doi.org/10.1016/j.eurox.2019.100045
Weghofer A, Munne S, Chen S, Barad D, Gleicher N. Lack of association between polycystic ovary syndrome and embryonic aneuploidy. Fertil Steril. 2007 Oct 1 [cited 2024 Feb 16];88(4):900–5. DOI: https://doi.org/10.1016/j.fertnstert.2006.12.018
Sahu B, Ozturk O, Ranierri M, Serhal P. Comparison of oocyte quality and intracytoplasmic sperm injection outcome in women with isolated polycystic ovaries or polycystic ovarian syndrome. Arch Gynecol Obstet. 2008 Mar [cited 2024 Feb 16];277(3):239–44. DOI: https://doi.org/10.1007/s00404-007-0462-x
Chappell NR, Barsky M, Shah J, Peavey M, Yang L, Sangi-Haghpeykar H, et al. Embryos from polycystic ovary syndrome patients with hyperandrogenemia reach morula stage faster than controls. F&S Reports. 2020 Sep 1 [cited 2024 Feb 16];1(2):125.DOI: https://doi.org/10.1016/j.xfre.2020.05.006
Meseguer M, Herrero J, Tejera A, Hilligsøe KM, Ramsing NB, Remoh J. The use of morphokinetics as a predictor of embryo implantation. Hum Reprod. 2011 [cited 2024 Feb 16];26(10):2658–71. DOI: https://doi.org/10.1093/humrep/der256
Lemmen JG, Agerholm I, Ziebe S. Kinetic markers of human embryo quality using time-lapse recordings of IVF/ICSI-fertilized oocytes. Reprod Biomed Online. 2008 [cited 2024 Feb 16];17(3):385–91. DOI: https://doi.org/10.1016/S1472-6483(10)60222-2
Huirne JAF, van Loenen ACD, Schats R McDonnell J, Hompes PGA, Schoemaker J, et al. Dose-finding study of daily GnRH antagonist for the prevention of premature LH surges in IVF/ICSI patients: optimal changes in LH and progesterone for clinical pregnancy. Hum Reprod. 2005 [cited 2024 Feb 18];20(2):359–67. DOI: https://doi.org/10.1093/humrep/deh601
Downloads
Published
How to Cite
Issue
Section
Categories
License
Copyright (c) 2024 Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright Notice
All articles submitted by the author and published in the Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan, are fully copyrighted by the publication of Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan under the Creative Commons Attribution-NonCommercial 4.0 International License by technically filling out the copyright transfer agreement and sending it to the publisher
Note :
The author can include in separate contractual arrangements for the non-exclusive distribution of rich versions of journal publications (for example: posting them to an institutional repository or publishing them in a book), with the acknowledgment of their initial publication in this journal.
Authors are permitted and encouraged to post their work online (for example: in an institutional repository or on their website) before and during the submission process because it can lead to productive exchanges, as well as earlier and more powerful citations of published works. (See Open Access Effects).
