Aplikasi Ekstrak Kulit Buah Naga Merah (Hylocereus polyrhizus) Pada Nata De Coco Dalam Menurunkan Kadar Kolesterol Total, LDL, Dan Meningkatkan HDL Pada Mencit (Mus musculus)
Keywords:Hylocereus polyrhizus, nata de coco, total cholesterol, LDL, HD
AbstractHypercholesterolemic sufferers generally consume conventional drugs using hypolipidemic drugs to reduce cholesterol levels. But this type of drug also has side effects. In addition to consuming hypolipidemic drugs, increased cholesterol levels can be suppressed by regulating dietary patterns by controlling nutrient intake in a balanced manner as needed. Red dragon fruit skin extract (Hylocereus polyrhizus) applied to nata de coco is believed to reduce cholesterol levels because both contain fiber which can be used for dietary needs, and improve the digestive process. The purpose of this study was to determine the application and determine the dose of red dragon fruit skin extract (Hylocereus polyrhizus) in nata de coco in reducing total cholesterol, LDL and increasing HDL in mice (Mus musculus). The type of research used is experimental research using the Pre-Post Test Only Control Group Design research design that uses 18 mices with different doses of 1: 1 and 1: 2 doses. ANOVA statistical test on the results of the study showed that effective treatment in reducing total cholesterol, LDL, and increasing HDL was treated with extracts of red dragon fruit skin (Hylocereus polyrhizus) in a 1: 2 nata de coco. Thus it can be concluded that the higher the dosage given to mice tested it showed a significant reduction in cholesterol levels.
Babio N, Balanza R, Basulto J, Bulló M, Salas-Salvadó J. Dietary fibre: influence on body weight, glycemic control and plasma cholesterol profile. Nutr Hosp. 2010;25(3):327−40.
Dhesti P. A. dan Widyaningsih. D. T. 2014. Pengaruh Pemberian Liang Teh Cincau Terhadap Kadar Kolesterol. Jurnal Pangan dan Agroindustri Vol.2 No.2 p.103-109. FTP Universitas Brawijaya Malang.
Heryani Reni. 2016. Pengaruh Ekstrak Buah Naga Merah Terhadap Profil Lipid Darah Tikus Putih Hiperlipidemia. Jurnal Ipteks Terapan. Research of Applied Science and Education V10.i1 (8-17).
Hillstrom RJ, Yacapin Ammons AK, Lynch SM. Biochemical and Molecular Actions of Nutrients Vitamin C Inhibits Lipid Oxidation in Human HDL 1 ,2. 2003; (April):3047–3051.
Kanner, J., Harel, S. & Granit, R. 2001. Betalains. A New Class of Dietary Cationized Antioxidants. J. Agr. Food Chem. 49: 5178-5185.
Lattimer JM, Haub MD. Effects of dietary fiber and its components on metabolic health. Nutrients. 2010;2(12):1266−1289.
Malloy M. J., Kane J.P. 2007. Agent Used in Hyperlipidemia. In: Katzung B.G.: Basic and Clinical Pharmacology. 10th ed. New York: Mac Graw Hill. P. 560-572
Maryanto, S dan Fatimah, S. 2004. Pengaruh Pemberian Jambu Biji (P. Guajava) Pada Lipid Serum Tikus Hiperkolesterolemia. Media Medika Indonesia 2004. 39(2):105:101
Merchant AT, et al. Interrelation of saturated fat, trans fat, alcohol intake, and subclinical atherosclerosis. 2008. Am J Clin Nutr; 87:168-174.
Mulyati T. dan Purwani N.P.R. 2012. Pengaruh Pemberian Nata De Coco Terhadap Kadar Kolesterol Pada Wanita Hiperkolesterolemia. Journal of Matrition College, Vol 1, No 1. Hal 249-257. UNDIP
Oliveira T, Ricardo KFS, Almeida MR, Costa MR, Nagem TJ. Hypolipidemic Effect of Flavonoids and Cholestyramine in Rats. Lat Am J Pharm. 2007;26(3):407-410
Saneto, B. 2005. Karakterisasi Kulit Buah Naga Merah (Hylocereus polyrhizus). Jurnal Agarika. Vol 2: 143-149.
How to Cite
All articles submitted by the author and published in the Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan, are fully copyrighted by the publication of Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan under the Creative Commons Attribution-NonCommercial 4.0 International License by technically filling out the copyright transfer agreement and sending it to the publisher
The author can include in separate contractual arrangements for the non-exclusive distribution of rich versions of journal publications (for example: posting them to an institutional repository or publishing them in a book), with the acknowledgment of their initial publication in this journal.
Authors are permitted and encouraged to post their work online (for example: in an institutional repository or on their website) before and during the submission process because it can lead to productive exchanges, as well as earlier and more powerful citations of published works. (See Open Access Effects).