Analysis of Urinary Endothelin-I Levels in Obese Late Adolescents


  • Dian Fahmi Utami Postgraduate Program in Physiology Concentration, Universitas Hasanuddin
  • Irfan Idris Department of Physiology, Universitas Hasanuddin
  • Arsyadi Arsyad Department of Physiology, Universitas Hasanuddin
  • Ika Yustisia Department of Biochemistry, Faculty of Medicine, Universitas Hasanuddin
  • A. Aryandi Department of Physiology, Faculty of Medicine, Universitas Hasanuddin
  • Husni Cangara Department of Anatomical Pathology, Faculty of Medicine, Universitas Hasanuddin



Obesity is a health problem that often occurs in late adolescents and early adults. Endothelial damage that occurs in obese people can cause increased production of endothelin-1. This study compares urinary endothelin-1 levels in the obese and normal groups. It used analytical research methods with a quantitative approach to collect and measure data in numbers. The study design was cross-sectional by comparing endothelin-1 levels in normal and obese adolescent groups. This research was conducted in Makassar City from April to June 2022. The study population was obese and non-obese people in their late teens and early adulthood. The sample collection technique used in this study is a purposive sampling technique, which is a non-random sampling technique. The number of samples in the study for the Obese group was 26, while in the Normal group was 26. The analysis used the Independent Sample T Test statistical test. The results showed that the average urinary endothelin I level in the obese group was 40,930 ng/l, and in the normal group, 55,547 ng/l. Which shows a significant difference in average endothelin I levels (p<0.05) between the obese and normal groups.


Abdelaal M, le Roux CW, Docherty NG. Morbidity and mortality associated with obesity. Ann Transl Med. 2017;5(7):1–12.

WHO. Obesity and Overweight. 2020.

Marseglia L, Manti S, D’Angelo G, Nicotera A, Parisi E, Di Rosa G, et al. Oxidative stress in obesity: A critical component in human diseases. Int J Mol Sci. 2015;16(1):378–400.

da Silva AA, Kuo JJ, Tallam LS, Hall JE. Role of Endothelin-1 in Blood Pressure Regulation in a Rat Model of Visceral Obesity and Hypertension. Hypertension. 2004;43(2):383–7.

Idris I, Sinrang AW, Arsyad A, Alwi S, Sandira MI. The rise of circulatory endothelin (ET)-1 and endothelin receptors (ETA, ETB) expression in kidney of obese wistar rat. Int J Physiol Pathophysiol Pharmacol. 2019;11(2):31–5.

John E. Hall, Guyton AC. Guyton and Hall : Medical Physiology. 2011.

Raina R, Chauvin A, Chakraborty R, Nair N, Shah H, Krishnappa V, et al. The Role of Endothelin and Endothelin Antagonists in Chronic Kidney Disease. Kidney Dis. 2020;6(1):22–34.

Weil BR, Westby CM, van Guilder GP, Greiner JJ, Stauffer BL, de Souza CA. Enhanced endothelin-1 system activity with overweight and obesity. Am J Physiol - Hear Circ Physiol. 2011;301(3):689–95.

Syarifuddin S, Purnamasari A. Perbandingan Kadar Endotelin-1 Sebagai. 2018;6:26–31.

Singh R, Verma A, Aljabari S, Vasylyeva TL. Urinary biomarkers as indicator of chronic inflammation and endothelial dysfunction in obese adolescents. BMC Obes. 2017;4(1):2–9.

Selvaraju V, Ayine P, Fadamiro M, Babu JR, Brown M, Geetha T. Urinary Biomarkers of Inflammation and Oxidative Stress Are Elevated in Obese Children and Correlate with a Marker of Endothelial Dysfunction. Oxid Med Cell Longev. 2019;2019.

Shin SJ, Lee YJ, Tsai JH. The correlation of plasma and urine endothelin-1 with the severity of nephropathy in Chinese patients with Type 2 diabetes. Scand J Clin Lab Invest. 1996;56(6):571–6.

Falkner B. Insulin resistance in African Americans. Kidney Int Suppl. 2003;63(83):27–30.

De Ciuceis C, Porteri E, Rizzoni D, Corbellini C, La Boria E, Boari GEM, et al. Effects of weight loss on structural and functional alterations of subcutaneous small arteries in obese patients. Hypertension. 2011;58(1):29–36.

Virdis A, Santini F, Colucci R, Duranti E, Salvetti G, Rugani I, et al. Vascular generation of tumor necrosis factor-α reduces nitric oxide availability in small arteries from visceral fat of obese patients. J Am Coll Cardiol [Internet]. 2011;58(3):238–47. Available from:

Grassi G, Seravalle G, Scopelliti F, Dell’Oro R, Fattori L, Quarti-Trevano F, et al. Structural and functional alterations of subcutaneous small resistance arteries in severe human obesity. Obesity. 2010;18(1):92–8.

Grundy SM. Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report. Circulation. 2002;106:3143–421.

Perez Del Villar C, Garcia Alonso CJ, Feldstein CA, Juncos LA, Romero JC. Role of endothelin in the pathogenesis of hypertension. Mayo Clin Proc. 2005;80(1):84–96.

Kohan DE, Barton M. Endothelin and endothelin antagonists in chronic kidney disease. Kidney Int. 2014;86(5):896–904.

Nambi P. Endothelin and the kidney. Adv Organ Biol. 2000;9(1):207–18.




How to Cite

Utami, D. F., Idris, I., Arsyad, A., Yustisia, I., Aryandi, A., & Cangara, H. (2022). Analysis of Urinary Endothelin-I Levels in Obese Late Adolescents. Jurnal Profesi Medika : Jurnal Kedokteran Dan Kesehatan, 16(2).